The dopamine D3-preferring D2/D3 dopamine receptor partial agonist, cariprazine, reverses behavioral changes in a rat neurodevelopmental model for schizophrenia

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The dopamine D3-preferring D2/D3 dopamine receptor partial agonist, cariprazine, reverses behavioral changes in a rat neurodevelopmental model for schizophrenia

Current antipsychotic medication is largely ineffective against the negative and cognitive symptoms of schizophrenia. One promising therapeutic development is to design new molecules that balance actions on dopamine D2 and D3 receptors to maximise benefits and limit adverse effects. This study used...

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Bibliographic Details
Main Authors:	Watson, David J.G., King, Madeleine V., Gyertyán, Istvan, Kiss, Béla, Adham, Nika, Fone, Kevin C.F.
Format:	Article
Published:	Elsevier 2016
Subjects:	Dopamine D3; Cariprazine; Social isolation; Neonatal phencyclidine; Object recognition; Schizophrenia
Online Access:	https://eprints.nottingham.ac.uk/34643/

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