Effects of white matter microstructure on phase and susceptibility maps
Purpose: To investigate the effects on quantitative susceptibility mapping (QSM) and susceptibility tensor imaging (STI) of the frequency variation produced by the microstructure of white matter (WM). Methods: The frequency offsets in a WM tissue sample that are not explained by the effect of bul...
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| Format: | Article |
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Wiley
2015
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| Online Access: | https://eprints.nottingham.ac.uk/34514/ |
| _version_ | 1848794871893065728 |
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| author | Wharton, Samuel Bowtell, Richard W. |
| author_facet | Wharton, Samuel Bowtell, Richard W. |
| author_sort | Wharton, Samuel |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Purpose: To investigate the effects on quantitative susceptibility mapping (QSM) and susceptibility tensor imaging (STI) of the frequency variation produced by the microstructure of white matter (WM).
Methods: The frequency offsets in a WM tissue sample that are not explained by the effect of bulk isotropic or anisotropic magnetic susceptibility, but rather result from the local microstructure, were characterized for the first time. QSM and STI were then applied to simulated frequency maps that were calculated using a digitized whole-brain, WM model formed from anatomical and diffusion tensor imaging data acquired from a volunteer. In this model, the magnitudes of the frequency contributions due to anisotropy and microstructure were derived from the results of the tissue experiments.
Results: The simulations suggest that the frequency contribution of microstructure is much larger than that due to bulk effects of anisotropic magnetic susceptibility. In QSM, the microstructure contribution introduced artificial WM heterogeneity. For the STI processing, the microstructure contribution caused the susceptibility anisotropy to be significantly overestimated.
Conclusion: Microstructure-related phase offsets in WM yield artifacts in the calculated susceptibility maps. If susceptibility mapping is to become a robust MRI technique, further research should be carried out to reduce the confounding effects of microstructure-related frequency contributions |
| first_indexed | 2025-11-14T19:23:05Z |
| format | Article |
| id | nottingham-34514 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:23:05Z |
| publishDate | 2015 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-345142020-05-04T17:02:35Z https://eprints.nottingham.ac.uk/34514/ Effects of white matter microstructure on phase and susceptibility maps Wharton, Samuel Bowtell, Richard W. Purpose: To investigate the effects on quantitative susceptibility mapping (QSM) and susceptibility tensor imaging (STI) of the frequency variation produced by the microstructure of white matter (WM). Methods: The frequency offsets in a WM tissue sample that are not explained by the effect of bulk isotropic or anisotropic magnetic susceptibility, but rather result from the local microstructure, were characterized for the first time. QSM and STI were then applied to simulated frequency maps that were calculated using a digitized whole-brain, WM model formed from anatomical and diffusion tensor imaging data acquired from a volunteer. In this model, the magnitudes of the frequency contributions due to anisotropy and microstructure were derived from the results of the tissue experiments. Results: The simulations suggest that the frequency contribution of microstructure is much larger than that due to bulk effects of anisotropic magnetic susceptibility. In QSM, the microstructure contribution introduced artificial WM heterogeneity. For the STI processing, the microstructure contribution caused the susceptibility anisotropy to be significantly overestimated. Conclusion: Microstructure-related phase offsets in WM yield artifacts in the calculated susceptibility maps. If susceptibility mapping is to become a robust MRI technique, further research should be carried out to reduce the confounding effects of microstructure-related frequency contributions Wiley 2015-02-18 Article PeerReviewed Wharton, Samuel and Bowtell, Richard W. (2015) Effects of white matter microstructure on phase and susceptibility maps. Magnetic Resonance in Medicine, 173 (3). pp. 1258-1269. ISSN 1522-2594 Quantitative susceptibility mapping; phase imaging; microstructure; white matter; anisotropy; gradient echo MRI http://onlinelibrary.wiley.com/doi/10.1002/mrm.25189/abstract doi:10.1002/mrm.25189 doi:10.1002/mrm.25189 |
| spellingShingle | Quantitative susceptibility mapping; phase imaging; microstructure; white matter; anisotropy; gradient echo MRI Wharton, Samuel Bowtell, Richard W. Effects of white matter microstructure on phase and susceptibility maps |
| title | Effects of white matter microstructure on phase and susceptibility maps |
| title_full | Effects of white matter microstructure on phase and susceptibility maps |
| title_fullStr | Effects of white matter microstructure on phase and susceptibility maps |
| title_full_unstemmed | Effects of white matter microstructure on phase and susceptibility maps |
| title_short | Effects of white matter microstructure on phase and susceptibility maps |
| title_sort | effects of white matter microstructure on phase and susceptibility maps |
| topic | Quantitative susceptibility mapping; phase imaging; microstructure; white matter; anisotropy; gradient echo MRI |
| url | https://eprints.nottingham.ac.uk/34514/ https://eprints.nottingham.ac.uk/34514/ https://eprints.nottingham.ac.uk/34514/ |