Biomarkers of liver fibrosis
Currently the only accepted method (gold standard) for the diagnosis of the fibrotic stages of chronic liver disease (CLD) is liver biopsy, to allow histological assessment. Liver biopsy is an invasive investigation associated with a range adverse events (e.g. pain, haemorrhage) limiting its serial...
| Main Authors: | , |
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| Format: | Article |
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Wiley
2016
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| Online Access: | https://eprints.nottingham.ac.uk/34456/ |
| _version_ | 1848794858102194176 |
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| author | Morling, Joanne R. Guha, Indra Neil |
| author_facet | Morling, Joanne R. Guha, Indra Neil |
| author_sort | Morling, Joanne R. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Currently the only accepted method (gold standard) for the diagnosis of the fibrotic stages of chronic liver disease (CLD) is liver biopsy, to allow histological assessment. Liver biopsy is an invasive investigation associated with a range adverse events (e.g. pain, haemorrhage) limiting its serial usage in clinical practice. Additionally, its use is further reduced by sampling error and because histology is in effect a surrogate for clinical outcomes.
Over recent years, alternative non-invasive biomarkers for the diagnosis of liver fibrosis have been developed. Initially developed in chronic viral hepatitis these have since seen their use expanded to include all aetiologies of CLD. Such markers can be divided into indirect ‘simple’ markers (e.g. transaminases, gamma-glutamyl transferase, platelet count), direct ‘complex’ markers (e.g. procollagen peptides I/III, Type IV collagen), cytokines (e.g. interleukin-10, transforming growth factor alpha) and imaging. Here, we discuss the clinical utility, limitations and development of non-invasive biomarkers in their use as diagnostic and prognostic tests. |
| first_indexed | 2025-11-14T19:22:52Z |
| format | Article |
| id | nottingham-34456 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:22:52Z |
| publishDate | 2016 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-344562020-05-04T17:54:54Z https://eprints.nottingham.ac.uk/34456/ Biomarkers of liver fibrosis Morling, Joanne R. Guha, Indra Neil Currently the only accepted method (gold standard) for the diagnosis of the fibrotic stages of chronic liver disease (CLD) is liver biopsy, to allow histological assessment. Liver biopsy is an invasive investigation associated with a range adverse events (e.g. pain, haemorrhage) limiting its serial usage in clinical practice. Additionally, its use is further reduced by sampling error and because histology is in effect a surrogate for clinical outcomes. Over recent years, alternative non-invasive biomarkers for the diagnosis of liver fibrosis have been developed. Initially developed in chronic viral hepatitis these have since seen their use expanded to include all aetiologies of CLD. Such markers can be divided into indirect ‘simple’ markers (e.g. transaminases, gamma-glutamyl transferase, platelet count), direct ‘complex’ markers (e.g. procollagen peptides I/III, Type IV collagen), cytokines (e.g. interleukin-10, transforming growth factor alpha) and imaging. Here, we discuss the clinical utility, limitations and development of non-invasive biomarkers in their use as diagnostic and prognostic tests. Wiley 2016-06-28 Article PeerReviewed Morling, Joanne R. and Guha, Indra Neil (2016) Biomarkers of liver fibrosis. Clinical Liver Disease, 7 (6). pp. 139-142. ISSN 2046-2484 http://onlinelibrary.wiley.com/doi/10.1002/cld.555/full doi:10.1002/cld.555 doi:10.1002/cld.555 |
| spellingShingle | Morling, Joanne R. Guha, Indra Neil Biomarkers of liver fibrosis |
| title | Biomarkers of liver fibrosis |
| title_full | Biomarkers of liver fibrosis |
| title_fullStr | Biomarkers of liver fibrosis |
| title_full_unstemmed | Biomarkers of liver fibrosis |
| title_short | Biomarkers of liver fibrosis |
| title_sort | biomarkers of liver fibrosis |
| url | https://eprints.nottingham.ac.uk/34456/ https://eprints.nottingham.ac.uk/34456/ https://eprints.nottingham.ac.uk/34456/ |