Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins

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Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins

Acyl hydrolase (AH) domains are a common feature of trans-AT PKSs. They have been hypothesised to perform a proofreading function by removing acyl chains from stalled sites. This study determines the substrate tolerance of the AH PedC for a range of acyl-ACPs. Clear preference towards short, linear...

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Bibliographic Details
Main Authors:	Jenner, Matthew, Afonso, José P., Kohlhaas, Christoph, Karbaum, Petra, Frank, Sarah, Piel, Jörn, Oldham, Neil J.
Format:	Article
Published:	Royal Society of Chemistry 2016
Online Access:	https://eprints.nottingham.ac.uk/34373/

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