Alternative RNA splicing: contribution to pain and potential therapeutic strategy
Since the sequencing of metazoan genomes began, it has become clear that the number of expressed proteins far exceeds the number of genes. It is now estimated that greater up to 98% of human genes give rise to multiple proteins through alternative pre-mRNA splicing. This review highlights the known...
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| Format: | Article |
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/34304/ |
| _version_ | 1848794820842094592 |
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| author | Donaldson, Lucy F. Beazley-Long, Nicholas |
| author_facet | Donaldson, Lucy F. Beazley-Long, Nicholas |
| author_sort | Donaldson, Lucy F. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Since the sequencing of metazoan genomes began, it has become clear that the number of expressed proteins far exceeds the number of genes. It is now estimated that greater up to 98% of human genes give rise to multiple proteins through alternative pre-mRNA splicing. This review highlights the known alternative splice variants of many channels, receptors and growth factors important in nociception and pain. Recently, pharmacological control of alternative splicing has been proposed as potential therapy in cancer, wet age-related macular degeneration, retroviral infections and pain. In this review we consider the effects that known splice variants of molecules key to nociception/pain have on nociceptive processing and/or analgesic action, and the potential for control of alternative pre-mRNA splicing as a novel analgesic strategy. |
| first_indexed | 2025-11-14T19:22:16Z |
| format | Article |
| id | nottingham-34304 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:22:16Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-343042020-05-04T17:55:57Z https://eprints.nottingham.ac.uk/34304/ Alternative RNA splicing: contribution to pain and potential therapeutic strategy Donaldson, Lucy F. Beazley-Long, Nicholas Since the sequencing of metazoan genomes began, it has become clear that the number of expressed proteins far exceeds the number of genes. It is now estimated that greater up to 98% of human genes give rise to multiple proteins through alternative pre-mRNA splicing. This review highlights the known alternative splice variants of many channels, receptors and growth factors important in nociception and pain. Recently, pharmacological control of alternative splicing has been proposed as potential therapy in cancer, wet age-related macular degeneration, retroviral infections and pain. In this review we consider the effects that known splice variants of molecules key to nociception/pain have on nociceptive processing and/or analgesic action, and the potential for control of alternative pre-mRNA splicing as a novel analgesic strategy. Elsevier 2016-06-18 Article PeerReviewed Donaldson, Lucy F. and Beazley-Long, Nicholas (2016) Alternative RNA splicing: contribution to pain and potential therapeutic strategy. Drug Discovery Today . ISSN 1359-6446 Alternative pre-mRNA splicing; ion channel; G-protein coupled receptor; growth factor; nociception; pain https://doi.org/10.1016/j.drudis.2016.06.017 doi:10.1016/j.drudis.2016.06.017 doi:10.1016/j.drudis.2016.06.017 |
| spellingShingle | Alternative pre-mRNA splicing; ion channel; G-protein coupled receptor; growth factor; nociception; pain Donaldson, Lucy F. Beazley-Long, Nicholas Alternative RNA splicing: contribution to pain and potential therapeutic strategy |
| title | Alternative RNA splicing: contribution to pain and potential therapeutic strategy |
| title_full | Alternative RNA splicing: contribution to pain and potential therapeutic strategy |
| title_fullStr | Alternative RNA splicing: contribution to pain and potential therapeutic strategy |
| title_full_unstemmed | Alternative RNA splicing: contribution to pain and potential therapeutic strategy |
| title_short | Alternative RNA splicing: contribution to pain and potential therapeutic strategy |
| title_sort | alternative rna splicing: contribution to pain and potential therapeutic strategy |
| topic | Alternative pre-mRNA splicing; ion channel; G-protein coupled receptor; growth factor; nociception; pain |
| url | https://eprints.nottingham.ac.uk/34304/ https://eprints.nottingham.ac.uk/34304/ https://eprints.nottingham.ac.uk/34304/ |