An epidemic in a dynamic population with importation of infectives

Consider a large uniformly mixing dynamic population, which has constant birth rate and exponentially distributed lifetimes, with mean population size $n$. A Markovian SIR (susceptible $\to$ infective $\to$ recovered) infectious disease, having importation of infectives, taking place in this popula...

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Main Authors: Ball, Frank, Britton, Tom, Trapman, Pieter
Format: Article
Published: Institute of Mathematical Statistics 2017
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Online Access:https://eprints.nottingham.ac.uk/34284/
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author Ball, Frank
Britton, Tom
Trapman, Pieter
author_facet Ball, Frank
Britton, Tom
Trapman, Pieter
author_sort Ball, Frank
building Nottingham Research Data Repository
collection Online Access
description Consider a large uniformly mixing dynamic population, which has constant birth rate and exponentially distributed lifetimes, with mean population size $n$. A Markovian SIR (susceptible $\to$ infective $\to$ recovered) infectious disease, having importation of infectives, taking place in this population is analysed. The main situation treated is where $n\to\infty$, keeping the basic reproduction number $R_0$ as well as the importation rate of infectives fixed, but assuming that the quotient of the average infectious period and the average lifetime tends to 0 faster than $1/\log n$. It is shown that, as $ n \to \infty$, the behaviour of the 3-dimensional process describing the evolution of the fraction of the population that are susceptible, infective and recovered, is encapsulated in a 1-dimensional regenerative process $S=\{ S(t);t\ge 0\}$ describing the limiting fraction of the population that are susceptible. The process $S$ grows deterministically, except at one random time point per regenerative cycle, where it jumps down by a size that is completely determined by the waiting time since the previous jump. Properties of the process $S$, including the jump size and stationary distributions, are determined.
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spelling nottingham-342842020-05-04T18:36:48Z https://eprints.nottingham.ac.uk/34284/ An epidemic in a dynamic population with importation of infectives Ball, Frank Britton, Tom Trapman, Pieter Consider a large uniformly mixing dynamic population, which has constant birth rate and exponentially distributed lifetimes, with mean population size $n$. A Markovian SIR (susceptible $\to$ infective $\to$ recovered) infectious disease, having importation of infectives, taking place in this population is analysed. The main situation treated is where $n\to\infty$, keeping the basic reproduction number $R_0$ as well as the importation rate of infectives fixed, but assuming that the quotient of the average infectious period and the average lifetime tends to 0 faster than $1/\log n$. It is shown that, as $ n \to \infty$, the behaviour of the 3-dimensional process describing the evolution of the fraction of the population that are susceptible, infective and recovered, is encapsulated in a 1-dimensional regenerative process $S=\{ S(t);t\ge 0\}$ describing the limiting fraction of the population that are susceptible. The process $S$ grows deterministically, except at one random time point per regenerative cycle, where it jumps down by a size that is completely determined by the waiting time since the previous jump. Properties of the process $S$, including the jump size and stationary distributions, are determined. Institute of Mathematical Statistics 2017-03-06 Article PeerReviewed Ball, Frank, Britton, Tom and Trapman, Pieter (2017) An epidemic in a dynamic population with importation of infectives. Annals of Applied Probability, 27 (1). pp. 242-274. ISSN 1050-5164 Branching process Regenerative process SIR epidemic Skorohod metric Weak convergence http://projecteuclid.org/euclid.aoap/1488790828 doi:10.1214/16-AAP1203 doi:10.1214/16-AAP1203
spellingShingle Branching process
Regenerative process
SIR epidemic
Skorohod metric
Weak convergence
Ball, Frank
Britton, Tom
Trapman, Pieter
An epidemic in a dynamic population with importation of infectives
title An epidemic in a dynamic population with importation of infectives
title_full An epidemic in a dynamic population with importation of infectives
title_fullStr An epidemic in a dynamic population with importation of infectives
title_full_unstemmed An epidemic in a dynamic population with importation of infectives
title_short An epidemic in a dynamic population with importation of infectives
title_sort epidemic in a dynamic population with importation of infectives
topic Branching process
Regenerative process
SIR epidemic
Skorohod metric
Weak convergence
url https://eprints.nottingham.ac.uk/34284/
https://eprints.nottingham.ac.uk/34284/
https://eprints.nottingham.ac.uk/34284/