Enantioselective nickel-catalyzed anti-carbometallative cyclizations of alkynyl electrophiles enabled by reversible alkenylnickel E/Z isomerization
Nickel-catalyzed additions of arylboronic acids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered ketones or enones, are reported. These reactions are reliant upon the formal anti-carbonickelation of the alkyne, which is postulated to occur by the rever...
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| Format: | Article |
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American Chemical Society
2016
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| Online Access: | https://eprints.nottingham.ac.uk/34188/ |
| _version_ | 1848794794067755008 |
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| author | Clarke, Christopher Incerti-Pradillos, Celia A. Lam, Hon Wai |
| author_facet | Clarke, Christopher Incerti-Pradillos, Celia A. Lam, Hon Wai |
| author_sort | Clarke, Christopher |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Nickel-catalyzed additions of arylboronic acids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered ketones or enones, are reported. These reactions are reliant upon the formal anti-carbonickelation of the alkyne, which is postulated to occur by the reversible E/Z isomerization of an alkenylnickel species. |
| first_indexed | 2025-11-14T19:21:51Z |
| format | Article |
| id | nottingham-34188 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:21:51Z |
| publishDate | 2016 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-341882020-05-04T17:55:32Z https://eprints.nottingham.ac.uk/34188/ Enantioselective nickel-catalyzed anti-carbometallative cyclizations of alkynyl electrophiles enabled by reversible alkenylnickel E/Z isomerization Clarke, Christopher Incerti-Pradillos, Celia A. Lam, Hon Wai Nickel-catalyzed additions of arylboronic acids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered ketones or enones, are reported. These reactions are reliant upon the formal anti-carbonickelation of the alkyne, which is postulated to occur by the reversible E/Z isomerization of an alkenylnickel species. American Chemical Society 2016-06-22 Article PeerReviewed Clarke, Christopher, Incerti-Pradillos, Celia A. and Lam, Hon Wai (2016) Enantioselective nickel-catalyzed anti-carbometallative cyclizations of alkynyl electrophiles enabled by reversible alkenylnickel E/Z isomerization. Journal of the American Chemical Society, 138 (26). pp. 8068-8071. ISSN 1520-5126 http://pubs.acs.org/doi/abs/10.1021/jacs.6b04206 doi:10.1021/jacs.6b04206 doi:10.1021/jacs.6b04206 |
| spellingShingle | Clarke, Christopher Incerti-Pradillos, Celia A. Lam, Hon Wai Enantioselective nickel-catalyzed anti-carbometallative cyclizations of alkynyl electrophiles enabled by reversible alkenylnickel E/Z isomerization |
| title | Enantioselective nickel-catalyzed anti-carbometallative cyclizations
of alkynyl electrophiles enabled by reversible alkenylnickel E/Z
isomerization |
| title_full | Enantioselective nickel-catalyzed anti-carbometallative cyclizations
of alkynyl electrophiles enabled by reversible alkenylnickel E/Z
isomerization |
| title_fullStr | Enantioselective nickel-catalyzed anti-carbometallative cyclizations
of alkynyl electrophiles enabled by reversible alkenylnickel E/Z
isomerization |
| title_full_unstemmed | Enantioselective nickel-catalyzed anti-carbometallative cyclizations
of alkynyl electrophiles enabled by reversible alkenylnickel E/Z
isomerization |
| title_short | Enantioselective nickel-catalyzed anti-carbometallative cyclizations
of alkynyl electrophiles enabled by reversible alkenylnickel E/Z
isomerization |
| title_sort | enantioselective nickel-catalyzed anti-carbometallative cyclizations
of alkynyl electrophiles enabled by reversible alkenylnickel e/z
isomerization |
| url | https://eprints.nottingham.ac.uk/34188/ https://eprints.nottingham.ac.uk/34188/ https://eprints.nottingham.ac.uk/34188/ |