Translating intracellular calcium signaling into models
The rich experimental data on intracellular calcium has put theoreticians in an ideal position to derive models of intracellular calcium signaling. Over the last 25 years, a large number of modeling frameworks have been suggested. Here, I will review some of the milestones of intracellular calcium m...
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| Format: | Article |
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Cold Spring Harbor Laboratory Press
2014
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| Online Access: | https://eprints.nottingham.ac.uk/34106/ |
| _version_ | 1848794776197922816 |
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| author | Thul, Ruediger |
| author_facet | Thul, Ruediger |
| author_sort | Thul, Ruediger |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The rich experimental data on intracellular calcium has put theoreticians in an ideal position to derive models of intracellular calcium signaling. Over the last 25 years, a large number of modeling frameworks have been suggested. Here, I will review some of the milestones of intracellular calcium modeling with a special emphasis on calcium-induced calcium release (CICR) through inositol-1,4,5-trisphosphate and ryanodine receptors. I will highlight key features of CICR and how they are represented in models as well as the challenges that theoreticians face when translating our current understanding of calcium signals into equations. The selected examples demonstrate that a successful model provides mechanistic insights into the molecular machinery of the Ca2+ signaling toolbox and determines the contribution of local Ca2+ release to global Ca2+ patterns, which at the moment cannot be resolved experimentally. |
| first_indexed | 2025-11-14T19:21:34Z |
| format | Article |
| id | nottingham-34106 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:21:34Z |
| publishDate | 2014 |
| publisher | Cold Spring Harbor Laboratory Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-341062020-05-04T16:48:02Z https://eprints.nottingham.ac.uk/34106/ Translating intracellular calcium signaling into models Thul, Ruediger The rich experimental data on intracellular calcium has put theoreticians in an ideal position to derive models of intracellular calcium signaling. Over the last 25 years, a large number of modeling frameworks have been suggested. Here, I will review some of the milestones of intracellular calcium modeling with a special emphasis on calcium-induced calcium release (CICR) through inositol-1,4,5-trisphosphate and ryanodine receptors. I will highlight key features of CICR and how they are represented in models as well as the challenges that theoreticians face when translating our current understanding of calcium signals into equations. The selected examples demonstrate that a successful model provides mechanistic insights into the molecular machinery of the Ca2+ signaling toolbox and determines the contribution of local Ca2+ release to global Ca2+ patterns, which at the moment cannot be resolved experimentally. Cold Spring Harbor Laboratory Press 2014-05-15 Article PeerReviewed Thul, Ruediger (2014) Translating intracellular calcium signaling into models. Cold Spring Harbor Protocols . pp. 463-471. ISSN 1559-6095 http://cshprotocols.cshlp.org/content/2014/5/pdb.top066266 doi:10.1101/pdb.top066266 doi:10.1101/pdb.top066266 |
| spellingShingle | Thul, Ruediger Translating intracellular calcium signaling into models |
| title | Translating intracellular calcium signaling into models |
| title_full | Translating intracellular calcium signaling into models |
| title_fullStr | Translating intracellular calcium signaling into models |
| title_full_unstemmed | Translating intracellular calcium signaling into models |
| title_short | Translating intracellular calcium signaling into models |
| title_sort | translating intracellular calcium signaling into models |
| url | https://eprints.nottingham.ac.uk/34106/ https://eprints.nottingham.ac.uk/34106/ https://eprints.nottingham.ac.uk/34106/ |