On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury

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On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury

The role of peroxisome proliferator activated alpha (PPARα) -mediated metabolic remodeling in cardiac adaptation to hypoxia has yet to be defined. Here, mice were housed in hypoxia for 3 weeks before in vivo contractile function was measured using cine magnetic resonance (MR) imaging. In isolated,...

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Bibliographic Details
Main Authors:	Cole, Mark, Abd Jamil, Amira H., Heather, Lisa C., Murray, Andrew J., Sutton, Elizabeth R., Slingo, Mary, Sebag-Montefiore, Liam, Tan, Suat Cheng, Aksentijević, Dunja, Gildea, Ottilie S., Stuckey, Daniel J., Yeoh, Kar Kheng, Carr, Carolyn A., Evans, Rhys D., Aasum, Ellen, Schofield, Christopher J., Ratcliffe, Peter J., Neubauer, Stefan, Robbins, Peter A., Clarke, Kieran
Format:	Article
Published:	Federation of American Society of Experimental Biology 2016
Subjects:	Cardiac contractile function; Cine magnetic resonance imaging; Hypoxia inducible factor (HIF); Myocardial energy metabolism; 31 P Magnetic resonance spectroscopy; Substrate metabolism
Online Access:	https://eprints.nottingham.ac.uk/34100/

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