Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure
The Drosophila heart is a linear organ formed by the movement of bilaterally specified progenitor cells to the midline and adherence of contralateral heart cells. This movement occurs through the attachment of heart cells to the overlying ectoderm which is undergoing dorsal closure. Therefore heart...
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| Format: | Article |
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Elsevier
2014
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| Online Access: | https://eprints.nottingham.ac.uk/34077/ |
| _version_ | 1848794769102209024 |
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| author | Haack, Timm Schneider, Matthias Schwendele, Bernd Renault, Andrew D. |
| author_facet | Haack, Timm Schneider, Matthias Schwendele, Bernd Renault, Andrew D. |
| author_sort | Haack, Timm |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The Drosophila heart is a linear organ formed by the movement of bilaterally specified progenitor cells to the midline and adherence of contralateral heart cells. This movement occurs through the attachment of heart cells to the overlying ectoderm which is undergoing dorsal closure. Therefore heart cells are thought to move to the midline passively. Through live imaging experiments and analysis of mutants that affect the speed of dorsal closure we show that heart cells in Drosophila are autonomously migratory and part of their movement to the midline is independent of the ectoderm. This means that heart formation in flies is more similar to that in vertebrates than previously thought. We also show that defects in dorsal closure can result in failure of the amnioserosa to properly degenerate, which can physically hinder joining of contralateral heart cells leading to a broken heart phenotype. |
| first_indexed | 2025-11-14T19:21:27Z |
| format | Article |
| id | nottingham-34077 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:21:27Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-340772020-05-04T16:58:39Z https://eprints.nottingham.ac.uk/34077/ Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure Haack, Timm Schneider, Matthias Schwendele, Bernd Renault, Andrew D. The Drosophila heart is a linear organ formed by the movement of bilaterally specified progenitor cells to the midline and adherence of contralateral heart cells. This movement occurs through the attachment of heart cells to the overlying ectoderm which is undergoing dorsal closure. Therefore heart cells are thought to move to the midline passively. Through live imaging experiments and analysis of mutants that affect the speed of dorsal closure we show that heart cells in Drosophila are autonomously migratory and part of their movement to the midline is independent of the ectoderm. This means that heart formation in flies is more similar to that in vertebrates than previously thought. We also show that defects in dorsal closure can result in failure of the amnioserosa to properly degenerate, which can physically hinder joining of contralateral heart cells leading to a broken heart phenotype. Elsevier 2014-12-15 Article PeerReviewed Haack, Timm, Schneider, Matthias, Schwendele, Bernd and Renault, Andrew D. (2014) Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure. Developmental Biology, 396 (2). pp. 169-182. ISSN 0012-1606 Dorsal vessel; Heart; Drosophila; wunen; Amnioserosa; Dorsal closure; Organogenesis http://dx.doi.org/10.1016/j.ydbio.2014.08.033 doi:10.1016/j.ydbio.2014.08.033 doi:10.1016/j.ydbio.2014.08.033 |
| spellingShingle | Dorsal vessel; Heart; Drosophila; wunen; Amnioserosa; Dorsal closure; Organogenesis Haack, Timm Schneider, Matthias Schwendele, Bernd Renault, Andrew D. Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure |
| title | Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure |
| title_full | Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure |
| title_fullStr | Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure |
| title_full_unstemmed | Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure |
| title_short | Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure |
| title_sort | drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure |
| topic | Dorsal vessel; Heart; Drosophila; wunen; Amnioserosa; Dorsal closure; Organogenesis |
| url | https://eprints.nottingham.ac.uk/34077/ https://eprints.nottingham.ac.uk/34077/ https://eprints.nottingham.ac.uk/34077/ |