The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials
In an appetitively motivated procedure, we have previously reported that systemic treatment with the dopamine (DA) D1 receptor agonist SKF81297 (0.4 and 0.8 mg/kg) depressed acquisition at a 2s inter-stimulus-interval (ISI), suitable to detect trace conditioning impairment. However since DA is invol...
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/34060/ |
| _version_ | 1848794765590528000 |
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| author | Pezze, Marie A. Marshall, Hayley J. Cassaday, Helen J. |
| author_facet | Pezze, Marie A. Marshall, Hayley J. Cassaday, Helen J. |
| author_sort | Pezze, Marie A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In an appetitively motivated procedure, we have previously reported that systemic treatment with the dopamine (DA) D1 receptor agonist SKF81297 (0.4 and 0.8 mg/kg) depressed acquisition at a 2s inter-stimulus-interval (ISI), suitable to detect trace conditioning impairment. However since DA is involved in reinforcement processes, the generality of effects across appetitively- and aversively-motivated trace conditioning procedures cannot be assumed. The present study tested the effects of SKF81297 (0.4 and 0.8 mg/kg) in an established conditioned emotional response (CER) procedure. Trace-dependent conditioning was clearly shown in two experiments: while conditioning was relatively strong at a 3-s ISI, it was attenuated at a 30-s ISI. This was shown after two (Experiment 1) or four (Experiment 2) conditioning trials conducted in - as far as possible - the same CER procedure. Contrary to prediction, in neither experiment was there any indication that trace conditioning was attenuated by treatment with 0.4 or 0.8 mg/kg SKF81297. In the same rats, locomotor activity was significantly enhanced at the 0.8 mg/kg dose of SKF81297. These results suggest that procedural details of the trace conditioning variant in use are an important determinant of the profile of dopaminergic modulation. |
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| id | nottingham-34060 |
| institution | University of Nottingham Malaysia Campus |
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| last_indexed | 2025-11-14T19:21:24Z |
| publishDate | 2016 |
| publisher | Elsevier |
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| spelling | nottingham-340602020-05-04T17:58:37Z https://eprints.nottingham.ac.uk/34060/ The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials Pezze, Marie A. Marshall, Hayley J. Cassaday, Helen J. In an appetitively motivated procedure, we have previously reported that systemic treatment with the dopamine (DA) D1 receptor agonist SKF81297 (0.4 and 0.8 mg/kg) depressed acquisition at a 2s inter-stimulus-interval (ISI), suitable to detect trace conditioning impairment. However since DA is involved in reinforcement processes, the generality of effects across appetitively- and aversively-motivated trace conditioning procedures cannot be assumed. The present study tested the effects of SKF81297 (0.4 and 0.8 mg/kg) in an established conditioned emotional response (CER) procedure. Trace-dependent conditioning was clearly shown in two experiments: while conditioning was relatively strong at a 3-s ISI, it was attenuated at a 30-s ISI. This was shown after two (Experiment 1) or four (Experiment 2) conditioning trials conducted in - as far as possible - the same CER procedure. Contrary to prediction, in neither experiment was there any indication that trace conditioning was attenuated by treatment with 0.4 or 0.8 mg/kg SKF81297. In the same rats, locomotor activity was significantly enhanced at the 0.8 mg/kg dose of SKF81297. These results suggest that procedural details of the trace conditioning variant in use are an important determinant of the profile of dopaminergic modulation. Elsevier 2016-08-01 Article PeerReviewed Pezze, Marie A., Marshall, Hayley J. and Cassaday, Helen J. (2016) The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials. Learning and Motivation, 55 . pp. 53-64. ISSN 0023-9690 Dopamine D1; Trace conditioning; Contextual conditioning; Rat; SKF81297 http://www.sciencedirect.com/science/article/pii/S0023969016300297 doi:10.1016/j.lmot.2016.06.001 doi:10.1016/j.lmot.2016.06.001 |
| spellingShingle | Dopamine D1; Trace conditioning; Contextual conditioning; Rat; SKF81297 Pezze, Marie A. Marshall, Hayley J. Cassaday, Helen J. The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials |
| title | The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials |
| title_full | The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials |
| title_fullStr | The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials |
| title_full_unstemmed | The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials |
| title_short | The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials |
| title_sort | dopamine d1 receptor agonist skf81297 has dose-related effects on locomotor activity but is without effect in a cer trace conditioning procedure conducted with two versus four trials |
| topic | Dopamine D1; Trace conditioning; Contextual conditioning; Rat; SKF81297 |
| url | https://eprints.nottingham.ac.uk/34060/ https://eprints.nottingham.ac.uk/34060/ https://eprints.nottingham.ac.uk/34060/ |