A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers

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A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers

The ability of G protein-coupled receptors (GPCRs) to form dimers, and particularly heterodimers, offers potential for targeted therapeutics with improved selectivity. However, studying dimer pharmacology is challenging, because of signaling cross-talk or because dimerization may often be transient...

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Bibliographic Details
Main Authors:	Kilpatrick, Laura E., Humphrys, Laura J., Holliday, Nicholas D.
Format:	Article
Published:	ASPET 2015
Online Access:	https://eprints.nottingham.ac.uk/34039/

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