A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers
The ability of G protein-coupled receptors (GPCRs) to form dimers, and particularly heterodimers, offers potential for targeted therapeutics with improved selectivity. However, studying dimer pharmacology is challenging, because of signaling cross-talk or because dimerization may often be transient...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Published: |
ASPET
2015
|
| Online Access: | https://eprints.nottingham.ac.uk/34039/ |