Strategies for measuring long-term control in atopic dermatitis trials: a systematic review
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. There are no standardised methods for capturing long-term control of AD. Objective: To identify how long-term control has been captured in published randomised controlled trials (RCTs). Resultswill initiate consensus discu...
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/33830/ |
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| author | Barbarot, Sebastien Rogers, Natasha K. Abuabara, Katrina Aubert, Helene Chalmers, Joanne Flohr, Carsten Hanfin, Jon Naldi, Luigi Margolis, David J. Paul, Carle Ridd, Matthew J. Schuttelaar, Marie-Louise Anna Simpson, Eric Tauber, Marie Volke, Annika Weidinger, Stephan Wilkes, Sally R. Wollenberg, Andreas Thomas, Kim S. |
| author_facet | Barbarot, Sebastien Rogers, Natasha K. Abuabara, Katrina Aubert, Helene Chalmers, Joanne Flohr, Carsten Hanfin, Jon Naldi, Luigi Margolis, David J. Paul, Carle Ridd, Matthew J. Schuttelaar, Marie-Louise Anna Simpson, Eric Tauber, Marie Volke, Annika Weidinger, Stephan Wilkes, Sally R. Wollenberg, Andreas Thomas, Kim S. |
| author_sort | Barbarot, Sebastien |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. There are no standardised methods for capturing long-term control of AD.
Objective: To identify how long-term control has been captured in published randomised controlled trials (RCTs). Resultswill initiate consensus discussions on how best to measure long-term control in the core outcome set for AD.
Methods: Systematic review of RCTs of AD treatments published between 2000 and 2013, with a follow-up period of ≥3 months, at least one outcome measure recorded at ≥3 time-points, full paper available, and published in English.
Results: 101/ 353 RCTs were eligible. Methods to capture long-term control included: repeated measurement of AD outcomes (92 RCTs; 91%), use of AD medication (29 RCTs; 28.7%); and AD flares/remissions (26 RCTs; 25.7%). Repeated measurements of AD outcomes were typically collected 3 to 5 times during a trial, but analysis methods often failed to make best use of the data. Time to first flare was most commonly for trials including flare data (21/52). Medication-use was recorded based on quantity, potency and frequency of application. Limitations: Included RCT data only
Conclusion: This review illustrates the difficulties in measuring long-term control, and points to the need for improved harmonization of outcomes. |
| first_indexed | 2025-11-14T19:20:34Z |
| format | Article |
| id | nottingham-33830 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:20:34Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-338302020-05-04T18:19:11Z https://eprints.nottingham.ac.uk/33830/ Strategies for measuring long-term control in atopic dermatitis trials: a systematic review Barbarot, Sebastien Rogers, Natasha K. Abuabara, Katrina Aubert, Helene Chalmers, Joanne Flohr, Carsten Hanfin, Jon Naldi, Luigi Margolis, David J. Paul, Carle Ridd, Matthew J. Schuttelaar, Marie-Louise Anna Simpson, Eric Tauber, Marie Volke, Annika Weidinger, Stephan Wilkes, Sally R. Wollenberg, Andreas Thomas, Kim S. Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. There are no standardised methods for capturing long-term control of AD. Objective: To identify how long-term control has been captured in published randomised controlled trials (RCTs). Resultswill initiate consensus discussions on how best to measure long-term control in the core outcome set for AD. Methods: Systematic review of RCTs of AD treatments published between 2000 and 2013, with a follow-up period of ≥3 months, at least one outcome measure recorded at ≥3 time-points, full paper available, and published in English. Results: 101/ 353 RCTs were eligible. Methods to capture long-term control included: repeated measurement of AD outcomes (92 RCTs; 91%), use of AD medication (29 RCTs; 28.7%); and AD flares/remissions (26 RCTs; 25.7%). Repeated measurements of AD outcomes were typically collected 3 to 5 times during a trial, but analysis methods often failed to make best use of the data. Time to first flare was most commonly for trials including flare data (21/52). Medication-use was recorded based on quantity, potency and frequency of application. Limitations: Included RCT data only Conclusion: This review illustrates the difficulties in measuring long-term control, and points to the need for improved harmonization of outcomes. Elsevier 2016-11-30 Article PeerReviewed Barbarot, Sebastien, Rogers, Natasha K., Abuabara, Katrina, Aubert, Helene, Chalmers, Joanne, Flohr, Carsten, Hanfin, Jon, Naldi, Luigi, Margolis, David J., Paul, Carle, Ridd, Matthew J., Schuttelaar, Marie-Louise Anna, Simpson, Eric, Tauber, Marie, Volke, Annika, Weidinger, Stephan, Wilkes, Sally R., Wollenberg, Andreas and Thomas, Kim S. (2016) Strategies for measuring long-term control in atopic dermatitis trials: a systematic review. Journal of the American Academy of Dermatology, 75 (5). pp. 1038-1044. ISSN 1523-1747 Atopic eczema; Atopic dermatitis; Long-term control; Outcome measures; RCTs; Systematic review; Flares. http://www.sciencedirect.com/science/article/pii/S0190962216303255 doi:10.1016/j.jaad.2016.05.043 doi:10.1016/j.jaad.2016.05.043 |
| spellingShingle | Atopic eczema; Atopic dermatitis; Long-term control; Outcome measures; RCTs; Systematic review; Flares. Barbarot, Sebastien Rogers, Natasha K. Abuabara, Katrina Aubert, Helene Chalmers, Joanne Flohr, Carsten Hanfin, Jon Naldi, Luigi Margolis, David J. Paul, Carle Ridd, Matthew J. Schuttelaar, Marie-Louise Anna Simpson, Eric Tauber, Marie Volke, Annika Weidinger, Stephan Wilkes, Sally R. Wollenberg, Andreas Thomas, Kim S. Strategies for measuring long-term control in atopic dermatitis trials: a systematic review |
| title | Strategies for measuring long-term control in atopic dermatitis trials: a systematic review |
| title_full | Strategies for measuring long-term control in atopic dermatitis trials: a systematic review |
| title_fullStr | Strategies for measuring long-term control in atopic dermatitis trials: a systematic review |
| title_full_unstemmed | Strategies for measuring long-term control in atopic dermatitis trials: a systematic review |
| title_short | Strategies for measuring long-term control in atopic dermatitis trials: a systematic review |
| title_sort | strategies for measuring long-term control in atopic dermatitis trials: a systematic review |
| topic | Atopic eczema; Atopic dermatitis; Long-term control; Outcome measures; RCTs; Systematic review; Flares. |
| url | https://eprints.nottingham.ac.uk/33830/ https://eprints.nottingham.ac.uk/33830/ https://eprints.nottingham.ac.uk/33830/ |