Mathematical and physical systems biology: application to pharmacokinetic drug-drug interactions and tumour growth

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Mathematical and physical systems biology: application to pharmacokinetic drug-drug interactions and tumour growth

In this thesis, a multi-scale approach is provided to a pharmacokinetic and a pharmacodynamic problem. The first part of this research provides a realistic mathematical physiological model of the liver to predict drug drug interactions (DDIs). The model describes the geometry of a lobule (liver u...

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Bibliographic Details
Main Author:	Cherkaoui Rbati, Mohammed
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2016
Subjects:	Modelling Pharmacokinetics Pharmacodynamics PBPK Multi-Scale ODE PDE Liver Inhibition Induction MBI Enzyme CYP Tumour Cancer Shedding Tumour Growth
Online Access:	https://eprints.nottingham.ac.uk/33719/

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