Identifying and targeting dormant cells in acute myeloid leukaemia

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Identifying and targeting dormant cells in acute myeloid leukaemia

Relapse in AML is thought to arise from dormant leukaemic cells that are characterised by low RNA synthesis activity, protected by the bone marrow (BM) niche, and may evade the effects of chemotherapeutic drugs. Our aim was to investigate agents which might be able to overcome chemoprotection by tar...

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Bibliographic Details
Main Author:	Yu, N.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2016
Subjects:	Drug resistance in cancer cells Chemoprotection Intrinsic apoptosis pathway Chemoresistance
Online Access:	https://eprints.nottingham.ac.uk/33679/

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