Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices
Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients. Accurate diagnosis at presentation and optimal long-term treatment is vital to mitigate ongoing neuroinflam...
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| Format: | Article |
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Springer
2016
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| Online Access: | https://eprints.nottingham.ac.uk/33485/ |
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| author | Chou, I-Jun Wang, Huei-Shyong Whitehouse, William P. Constantinescu, Cris S. |
| author_facet | Chou, I-Jun Wang, Huei-Shyong Whitehouse, William P. Constantinescu, Cris S. |
| author_sort | Chou, I-Jun |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients. Accurate diagnosis at presentation and optimal long-term treatment is vital to mitigate ongoing neuroinflammation and irreversible neurodegeneration.
However, it may be difficult to early differentiate pediatric MS from acute disseminated
encephalomyelitis (ADEM) and neuromyelitis optica spectrum disorders (NMOSD) as they often have atypical presentation that differs from that of adult-onset MS. The
purpose of this review is to summarize the updated views on diagnostic criteria, imaging, histopathology and treatment choices. |
| first_indexed | 2025-11-14T19:19:25Z |
| format | Article |
| id | nottingham-33485 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:19:25Z |
| publishDate | 2016 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-334852020-05-04T17:57:32Z https://eprints.nottingham.ac.uk/33485/ Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices Chou, I-Jun Wang, Huei-Shyong Whitehouse, William P. Constantinescu, Cris S. Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients. Accurate diagnosis at presentation and optimal long-term treatment is vital to mitigate ongoing neuroinflammation and irreversible neurodegeneration.
However, it may be difficult to early differentiate pediatric MS from acute disseminated
encephalomyelitis (ADEM) and neuromyelitis optica spectrum disorders (NMOSD) as they often have atypical presentation that differs from that of adult-onset MS. The
purpose of this review is to summarize the updated views on diagnostic criteria, imaging, histopathology and treatment choices. Springer 2016-06-06 Article PeerReviewed Chou, I-Jun, Wang, Huei-Shyong, Whitehouse, William P. and Constantinescu, Cris S. (2016) Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices. Current Neurology and Neuroscience Reports, 16 (7). pp. 1-12. ISSN 1534-6293 ADEM; CIS; Demyelination; MRI; NMOSD http://link.springer.com/article/10.1007%2Fs11910-016-0663-4 doi:10.1007/s11910-016-0663-4 doi:10.1007/s11910-016-0663-4 |
| spellingShingle | ADEM; CIS; Demyelination; MRI; NMOSD Chou, I-Jun Wang, Huei-Shyong Whitehouse, William P. Constantinescu, Cris S. Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices |
| title | Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices |
| title_full | Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices |
| title_fullStr | Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices |
| title_full_unstemmed | Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices |
| title_short | Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices |
| title_sort | pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices |
| topic | ADEM; CIS; Demyelination; MRI; NMOSD |
| url | https://eprints.nottingham.ac.uk/33485/ https://eprints.nottingham.ac.uk/33485/ https://eprints.nottingham.ac.uk/33485/ |