Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes
Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one mean by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can interfere with bacterial adhesion or the chemical...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Nature Publishing Group
2013
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/3302/ |
| _version_ | 1848790997548400640 |
|---|---|
| author | Lui, Leong T. Xue, Xuan Sui, Cheng Brown, Alan Pritchard, David I. Halliday, Nigel Winzer, Klaus Howdle, Stephen M. Fernandez-Trillo, Francisco Krasnogor, Natalio Alexander, Cameron |
| author_facet | Lui, Leong T. Xue, Xuan Sui, Cheng Brown, Alan Pritchard, David I. Halliday, Nigel Winzer, Klaus Howdle, Stephen M. Fernandez-Trillo, Francisco Krasnogor, Natalio Alexander, Cameron |
| author_sort | Lui, Leong T. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one mean by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can interfere with bacterial adhesion or the chemical reactions used for quorum sensing are thus a potential means to control bacterial population responses. Here we report how polymeric "bacteria sequestrants", designed to bind to bacteria through electrostatic interactions and thus inhibit bacterial adhesion to surfaces, induce the expression of quorum sensing controlled phenotypes as a consequence of cell clustering. A combination of polymer and analytical chemistry, biological assays and computational modelling has been used to characterise the feedback between bacteria clustering and quorum sensing signaling. We have also derived design principles and chemical strategies for controlling bacterial behaviour at the population level |
| first_indexed | 2025-11-14T18:21:30Z |
| format | Article |
| id | nottingham-3302 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:21:30Z |
| publishDate | 2013 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-33022020-05-04T20:18:25Z https://eprints.nottingham.ac.uk/3302/ Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes Lui, Leong T. Xue, Xuan Sui, Cheng Brown, Alan Pritchard, David I. Halliday, Nigel Winzer, Klaus Howdle, Stephen M. Fernandez-Trillo, Francisco Krasnogor, Natalio Alexander, Cameron Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one mean by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can interfere with bacterial adhesion or the chemical reactions used for quorum sensing are thus a potential means to control bacterial population responses. Here we report how polymeric "bacteria sequestrants", designed to bind to bacteria through electrostatic interactions and thus inhibit bacterial adhesion to surfaces, induce the expression of quorum sensing controlled phenotypes as a consequence of cell clustering. A combination of polymer and analytical chemistry, biological assays and computational modelling has been used to characterise the feedback between bacteria clustering and quorum sensing signaling. We have also derived design principles and chemical strategies for controlling bacterial behaviour at the population level Nature Publishing Group 2013-12 Article PeerReviewed Lui, Leong T., Xue, Xuan, Sui, Cheng, Brown, Alan, Pritchard, David I., Halliday, Nigel, Winzer, Klaus, Howdle, Stephen M., Fernandez-Trillo, Francisco, Krasnogor, Natalio and Alexander, Cameron (2013) Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes. Nature Chemistry, 5 (12). pp. 1058-1065. ISSN 1755-4349 Polymers bacteria quorum sensing molecular recognition synthetic biology http://www.nature.com/nchem/journal/v5/n12/full/nchem.1793.html doi:10.1038/nchem.1793 doi:10.1038/nchem.1793 |
| spellingShingle | Polymers bacteria quorum sensing molecular recognition synthetic biology Lui, Leong T. Xue, Xuan Sui, Cheng Brown, Alan Pritchard, David I. Halliday, Nigel Winzer, Klaus Howdle, Stephen M. Fernandez-Trillo, Francisco Krasnogor, Natalio Alexander, Cameron Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes |
| title | Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes |
| title_full | Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes |
| title_fullStr | Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes |
| title_full_unstemmed | Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes |
| title_short | Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes |
| title_sort | bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes |
| topic | Polymers bacteria quorum sensing molecular recognition synthetic biology |
| url | https://eprints.nottingham.ac.uk/3302/ https://eprints.nottingham.ac.uk/3302/ https://eprints.nottingham.ac.uk/3302/ |