Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90

QR Code

Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90

A series of macrolactam analogues of the naturally occurring resorcylic acid lactone radicicol have been synthesised from methyl orsellinate in 7 steps, involving chlorination, protection of the two phenolic groups, and hydrolysis to the benzoic acid. Formation of the dianion and quenching with a We...

Full description

Bibliographic Details
Main Authors:	Dutton, Bridie L., Kitson, Russell R.A., Parry-Morris, Sarah, Roe, S. Mark, Prodromou, Chrisostomos, Moody, Christopher J.
Format:	Article
Published:	Royal Society of Chemistry 2014
Online Access:	https://eprints.nottingham.ac.uk/3299/

Similar Items

Isolation and characterization of heat-shock protein 90 (hsp90) specific promoter of Cryptocoryne ciliata
by: Zairul-Fazwan, M.Z., et al.
Published: (2015)

Differential gene expression of heat shock protein 90 (Hsp90) of Candida albicans obtained from Malaysian and Iranian patients
by: Khalili, Vajihe, et al.
Published: (2016)

Purification and comparison of heat shock protein 90 (Hsp90) in Candida albicans isolates from Malaysian and Iranian patients and infected mice
by: Khalili, Vajihe, et al.
Published: (2016)

Determination severity of pneumonia, responses of heat shock protein 90 (HSP 90) and cortisol concentrations in vaccinated and non-vaccinated pneumonic and non-pneumonic goats
by: Ahmad Tarmizi Tan, Ahmad Hafizin
Published: (2018)

Comparison of candida HSP90 protein content and gene expression in Iranian and Malaysian candida-infected patients
by: Khalili, Vajihozaman
Published: (2013)

Sequence polymorphism of heat shock protein 70 (HSP70) gene in kelampayan (Neolamarckia cadamba)
by: Choo, Hui Yik
Published: (2011)

Molecular importance of prawn large heat shock proteins 60, 70 and 90
by: Chaurasia, Mukesh Kumar, et al.
Published: (2016)

Role of OsFKBP62-OsHSP90-OsHSFA2 pathway in regulating thermotolerance in rice (Oryza sativa L.)
by: Ng'ang'a, Maureen
Published: (2025)

Heat shock protein expression analysis in canine osteosarcoma reveals HSP60 as a potentially relevant therapeutic target
by: Selvarajah, Gayathri Thevi, et al.
Published: (2013)

Association between physiological responses and heat shock protein 70 (HSP70) expressions in the vulnerable populations of Kuala Lumpur
by: Muhamad, Siti Nurfahirah, et al.
Published: (2024)

Heat stress-induced heat shock protein 70 (HSP70) expressions among vulnerable populations in urban and rural areas Klang Valley, Malaysia
by: Muhamad, Siti Nurfahirah, et al.
Published: (2025)

Characterisation of the MALT90 survey and the Mopra telescope at 90 GHz
by: Walsh, Andrew, et al.
Published: (2013)

Optimization of storage conditions for the detection of Heat Shock Protein 70 (HSP70) from salivary glands of field collected Aedes albopictus / Nur Azimah Sulong
by: Sulong, Nur Azimah
Published: (2015)

Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
by: Althiabat, Mohammad Gasem Mohammad
Published: (2020)

MALT90: The Millimetre Astronomy Legacy Team 90 GHz Survey
by: Jackson, J., et al.
Published: (2013)

Zygmunt Bauman at 90
by: Beilharz, Peter
Published: (2015)

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic ß-cell dysfunction and death in vitro.
by: Krause, M., et al.
Published: (2013)

90 peratus dapat tawaran
by: Yusoff Bakri, Mohamad Hafiz
Published: (2019)

Effects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter
by: Kostrycki, I., et al.
Published: (2019)

Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans
by: Dawe, Adam S., et al.
Published: (2008)

Comparative docking studies of rosmarinic acid and sinesitin to inhibit HSP70
by: V., Mansoureh Nazari, et al.
Published: (2019)

Molecular analysis of Hsp70 mechanisms in plants and their function in response to stress
by: Usman, Magaji G., et al.
Published: (2017)

90 lesen pengilang biodiesel dilulus
Published: (2008)

Kempen kesedaran 90 hari VAW
by: Utusan Malaysia,
Published: (2015)

Synthesis of toxyloxanthone B
by: Giallombardoa, Daniele, et al.
Published: (2014)

'You see, it's sort of tricky for the L2-user': the puzzle of idiomaticity in English as a lingua franca
by: Prodromou, Luke
Published: (2005)

90 peratus siswazah UMP diterima bekerja
by: UMP, LIB
Published: (2010)

90% of Malaysians projected to be living in cities by 2050
by: The Edge
Published: (2016)

Impak, rasional cuti bersalin 90 hari
by: Abd Rahman, Muhammad Daaniyall
Published: (2019)

Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?
by: Rodrigues-Krause, J., et al.
Published: (2012)

In Silico Optimisation Of Domain Antibodies Against HSP16.3 From Mycobacterium Tuberculosis
by: Soong, Jia Xin
Published: (2018)

Simulation results of pipe whip impact at 90° angle
by: Shah, Qasim Hussain, et al.
Published: (2011)

90 pelajar antarabangsa rasai pengalaman masuk kampung
by: Kosmo,
Published: (2017)

90 high-risk trees in KL to be felled by July
by: Bernama, .
Published: (2024)

Molecular Identification of Nontuberculous Mycobacteria from Clinical Sources by hsp65 PRA and Sequence Analysis
by: Ong, Chia Sui, et al.
Published: (2008)

The expression of target HSP70 gene and membrane stability determine heat tolerance in chili pepper
by: Usman, Magaji G., et al.
Published: (2015)

Bleeding & shock
by: Che Abdullah, Che Azunie
Published: (2016)

Some Analogue of Cramer-Shoup
by: Md. Said, Mohamad Rushdan, et al.
Published: (2008)

Dasar 10:90 ambil pelajar IPTA sesi depan
Published: (2008)

Theoretical considerations in urban low-income housing provision in the 90s
by: Abd. Mutalip, Abdullah
Published: (2006)