Synthesis of toxyloxanthone B

QR Code

Synthesis of toxyloxanthone B

A synthesis of the naturally occurring xanthone toxyloxanthone B is described, in which the key step is the regioselective addition of a methyl salicylate to a substituted benzyne followed by cyclization of the intermediate aryl anion to form the xanthone, the regiochemistry of the aryne addition be...

Full description

Bibliographic Details
Main Authors:	Giallombardoa, Daniele, Nevin, Adam C., Lewis, William, Nawrat, Christopher C., Kitson, Russell R.A., Moody, Christopher J.
Format:	Article
Published:	Elsevier 2014
Online Access:	https://eprints.nottingham.ac.uk/3298/

Similar Items

Quinones as dienophiles in the Diels-Alder reaction: history and applications in total synthesis
by: Nawrat, Christopher C., et al.
Published: (2014)

Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90
by: Dutton, Bridie L., et al.
Published: (2014)

Total synthesis of the cyclic dodecapeptides wewakazole and wewakazole B
by: Inman, Martyn, et al.
Published: (2017)

Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction
by: Nicolle, Simon M., et al.
Published: (2015)

Stereoselective synthesis of functionalized pyrrolidines by the diverted NH insertion reaction of metallocarbenes with β-aminoketone derivatives
by: Nicolle, Simon M., et al.
Published: (2016)

Total synthesis of the post-translationally modified polyazole peptide antibiotic goadsporin
by: Dexter, Hannah L., et al.
Published: (2017)

Synthesis of highly substituted 1,2-diazetidin-3-ones, small ring scaffolds for drug discovery
by: Santos, Marilla S., et al.
Published: (2018)

Copper(II)-mediated synthesis of indolequinones from bromoquinones and enamines
by: Inman, Martyn, et al.
Published: (2013)

Refining pore size, functionality and stability in porous hybrid frameworks
by: Nevin, Adam C
Published: (2017)

Natural quinones and their analogues: synthesis, intracellular redox cycling and identification of indoleamine-2,3-dioxygenase (IDO) as a potential target for anticancer activity
by: Blunt, Christopher, et al.
Published: (2015)

Diastereoselective synthesis of highly substituted, amino- and pyrrolidino-tetrahydrofurans as lead-like molecular scaffolds
by: Moody, Christopher J., et al.
Published: (2018)

Total synthesis of the post-translationally modified polyazole peptide antibiotic plantazolicin A
by: Wada, Hiroki, et al.
Published: (2015)

C–H insertion as a key step to spiro-oxetanes, scaffolds for drug discovery
by: Nicolle, Simon M., et al.
Published: (2017)

Nitrogen-Bridged, Natural Product-Like Octahydrobenzofurans and Octahydroindoles: Scope and Mechanism of Bridge-Forming Reductive Amination via Caged Heteroadamantanes
by: Wales, Steven M., et al.
Published: (2018)

Seven-membered ring scaffolds for drug discovery: access to functionalised azepanes and oxepanes through diazocarbonyl chemistry
by: Nortcliffe, Andrew, et al.
Published: (2015)

Visible light mediated oxidation of benzylic sp3 C–H bonds using catalytic 1,4hydroquinone, or its biorenewable glucoside, arbutin, as a pre-oxidant
by: Finney, Laura C., et al.
Published: (2018)

Total synthesis of (−)-aritasone via the ultra-high pressure hetero-Diels–Alder dimerisation of (−)-pinocarvone
by: Uroos, Maliha, et al.
Published: (2017)

Enantioselective synthesis of chiral cyclopent-2-enones by nickel-catalyzed desymmetrization of malonate esters
by: Karad, Somnath Narayan, et al.
Published: (2018)

Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position
by: Cousin, David, et al.
Published: (2018)

Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery
by: Geary, Gemma C., et al.
Published: (2017)

Expedient synthesis of an atypical oxazolidinone compound library
by: Cully, Sarah J., et al.
Published: (2016)

Expedient synthesis of an atypical oxazolidinone compound library
by: Cully, Sarah J., et al.
Published: (2016)

The Effect of 17b-Estradiol on the Development of Modified Hemal Spines in Early–Life Stage Gambusia holbrooki
by: Rawson, Christopher, et al.
Published: (2006)

Sulfonimidates: useful synthetic intermediates for sulfoximine synthesis via C–S bond formation
by: Matos, Priscilla Mendonça, et al.
Published: (2018)

Single nucleotide polymorphisms in bovine chemokine and toll-like receptors : impacts on disease susceptibility and productivity in dairy cattle
by: Russell, Christopher David
Published: (2013)

Supramolecular network formation from solution-based deposition techniques
by: Russell, James Christopher
Published: (2011)

Silent victims: why do battered husbands in Malaysia not come out of the closet? / Kitson Foong
by: Kitson, Foong
Published: (2008)

Continuous-flow hydrothermal and solvothermal synthesis of inorganic nanomaterials
by: Starkey, Christopher L.
Published: (2016)

Synthesis of highly porous poly(tert-butyl acrylate)-b-polysulfone-b-poly(tert-butyl acrylate) asymmetric membranes
by: Xie, Y., et al.
Published: (2016)

Search for nonresonant Higgs boson pair production in the b b ¯ b b ¯ final state at √s = 13 TeV
by: Sirunyan, A. M., et al.
Published: (2019)

Incidence of venous thromboembolism following colorectal surgery
by: Lewis-Lloyd, Christopher A.
Published: (2023)

Development of a series of bis-triazoles as G-quadruplex ligands
by: Saleh, Maysaa, et al.
Published: (2017)

Looking Again: Violence, Photography, Spectatorship, and Conflict Images of Children
by: Lewis, Christopher Dennis
Published: (2016)

The design, synthesis and characterisation of amine functionalised silica adsorbents for post combustion carbon capture
by: Starkie, Christopher
Published: (2016)

Asymmetric piperidine synthesis
by: Lewis, Neil
Published: (1995)

MYC regulation of Glutamine-Proline regulatory axis is key in Luminal B breast cancer
by: Craze, Madeleine L., et al.
Published: (2017)

Design, synthesis and evaluation of fluorescent CB2 cannabinoid receptor ligands
by: Holt, Christopher James
Published: (2009)

Studies towards the biomimetic synthesis of members of the kingianin family of natural products
by: Moore, Jonathan Christopher
Published: (2016)

Catalytic Conversion of CO2 Using Bi-reforming and Methanol Synthesis
by: Acquarola, Christopher Michael
Published: (2024)

Synthesis and characterization of Ag/TiO2-B nanosquares with high photocatalytic activity under visible light irradiation
by: Yu, C., et al.
Published: (2013)