A study of DEF6 granule formation using biophysical and cellular methods

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A study of DEF6 granule formation using biophysical and cellular methods

DEF6 is a Rho-Guanine Nucleotide Exchange Factor (GEF) with a poorly characterised role in T-cell receptor signalling and unknown structure1-3. Its importance in T-cell signalling has been highlighted by observations that DEF6-deficient T cells display defective actin polymerisation and polarisation...

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Bibliographic Details
Main Author:	Mollett, Eleanor
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2015
Online Access:	https://eprints.nottingham.ac.uk/32911/

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