Glycosylated notch and cancer
Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the a...
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| Format: | Article |
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Frontiers in Oncology
2016
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| Online Access: | https://eprints.nottingham.ac.uk/32819/ |
| _version_ | 1848794496752418816 |
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| author | Pakkiriswami, Shanmugasundaram Couto, Africa Nagarajan, Usha Georgiou, Marios |
| author_facet | Pakkiriswami, Shanmugasundaram Couto, Africa Nagarajan, Usha Georgiou, Marios |
| author_sort | Pakkiriswami, Shanmugasundaram |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis. |
| first_indexed | 2025-11-14T19:17:07Z |
| format | Article |
| id | nottingham-32819 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:17:07Z |
| publishDate | 2016 |
| publisher | Frontiers in Oncology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-328192020-05-04T17:36:34Z https://eprints.nottingham.ac.uk/32819/ Glycosylated notch and cancer Pakkiriswami, Shanmugasundaram Couto, Africa Nagarajan, Usha Georgiou, Marios Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis. Frontiers in Oncology 2016-02-18 Article PeerReviewed Pakkiriswami, Shanmugasundaram, Couto, Africa, Nagarajan, Usha and Georgiou, Marios (2016) Glycosylated notch and cancer. Frontiers in Oncology, 6 (37). ISSN 2234-943X Glycosyltransferases; Notch signaling; Tumorigenesis; Epidermal growth factor http://journal.frontiersin.org/article/10.3389/fonc.2016.00037/full doi:10.3389/fonc.2016.00037 doi:10.3389/fonc.2016.00037 |
| spellingShingle | Glycosyltransferases; Notch signaling; Tumorigenesis; Epidermal growth factor Pakkiriswami, Shanmugasundaram Couto, Africa Nagarajan, Usha Georgiou, Marios Glycosylated notch and cancer |
| title | Glycosylated notch and cancer |
| title_full | Glycosylated notch and cancer |
| title_fullStr | Glycosylated notch and cancer |
| title_full_unstemmed | Glycosylated notch and cancer |
| title_short | Glycosylated notch and cancer |
| title_sort | glycosylated notch and cancer |
| topic | Glycosyltransferases; Notch signaling; Tumorigenesis; Epidermal growth factor |
| url | https://eprints.nottingham.ac.uk/32819/ https://eprints.nottingham.ac.uk/32819/ https://eprints.nottingham.ac.uk/32819/ |