Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies
Objectives To examine the prevalence of synovial effusion, synovial hypertrophy and positive Doppler signal (DS) detected by ultrasound (US) in people with knee osteoarthritis (OA) and/or knee pain compared to that in the general population. Method A systematic literature search was undertaken...
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| Format: | Article |
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/32813/ |
| _version_ | 1848794495008636928 |
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| author | Sarmanov, Aliya Hall, Michelle C. Moses, Jonathan Doherty, Michael Zhang, Weiya |
| author_facet | Sarmanov, Aliya Hall, Michelle C. Moses, Jonathan Doherty, Michael Zhang, Weiya |
| author_sort | Sarmanov, Aliya |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objectives
To examine the prevalence of synovial effusion, synovial hypertrophy and positive Doppler signal (DS) detected by ultrasound (US) in people with knee osteoarthritis (OA) and/or knee pain compared to that in the general population.
Method
A systematic literature search was undertaken in Medline, EMBASE, Allied and Complementary Medicine, PubMed Web of Science, and SCOPUS databases in May 2015. Frequencies of US abnormalities in people with knee OA/pain, in the general population or asymptomatic controls were pooled using the random effects model. Publication bias and heterogeneity between studies were examined.
Results
Twenty four studies in people with knee pain/OA and five studies of the general population or asymptomatic controls met the inclusion criteria. The pooled prevalence of US effusion, synovial hypertrophy and positive DS in people with knee OA/pain were 51.5% (95% CI 40.2 to 62.8), 41.5% (26.3–57.5) and 32.7% (8.34–63.24), respectively, which were higher than those in the general population or asymptomatic controls (19.9% (95%CI 7.8–35.3%), 14.5% (0–58.81), and 15.8 (3.08–35.36), respectively). People with knee OA (ACR criteria or radiographic OA) had greater prevalence of US abnormalities than people with knee pain (P = 0.037, P = 0.010 and P = 0.009, respectively).
Conclusions
US detected effusion, synovial hypertrophy and DS are more common in people with knee OA/pain, compared to the general population. These abnormalities relate more to presence of OA structural changes than to pain. |
| first_indexed | 2025-11-14T19:17:06Z |
| format | Article |
| id | nottingham-32813 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:17:06Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-328132020-05-04T17:42:18Z https://eprints.nottingham.ac.uk/32813/ Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies Sarmanov, Aliya Hall, Michelle C. Moses, Jonathan Doherty, Michael Zhang, Weiya Objectives To examine the prevalence of synovial effusion, synovial hypertrophy and positive Doppler signal (DS) detected by ultrasound (US) in people with knee osteoarthritis (OA) and/or knee pain compared to that in the general population. Method A systematic literature search was undertaken in Medline, EMBASE, Allied and Complementary Medicine, PubMed Web of Science, and SCOPUS databases in May 2015. Frequencies of US abnormalities in people with knee OA/pain, in the general population or asymptomatic controls were pooled using the random effects model. Publication bias and heterogeneity between studies were examined. Results Twenty four studies in people with knee pain/OA and five studies of the general population or asymptomatic controls met the inclusion criteria. The pooled prevalence of US effusion, synovial hypertrophy and positive DS in people with knee OA/pain were 51.5% (95% CI 40.2 to 62.8), 41.5% (26.3–57.5) and 32.7% (8.34–63.24), respectively, which were higher than those in the general population or asymptomatic controls (19.9% (95%CI 7.8–35.3%), 14.5% (0–58.81), and 15.8 (3.08–35.36), respectively). People with knee OA (ACR criteria or radiographic OA) had greater prevalence of US abnormalities than people with knee pain (P = 0.037, P = 0.010 and P = 0.009, respectively). Conclusions US detected effusion, synovial hypertrophy and DS are more common in people with knee OA/pain, compared to the general population. These abnormalities relate more to presence of OA structural changes than to pain. Elsevier 2016-03-10 Article PeerReviewed Sarmanov, Aliya, Hall, Michelle C., Moses, Jonathan, Doherty, Michael and Zhang, Weiya (2016) Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies. Osteoarthritis and Cartilage . ISSN 1522-9653 ultrasound; synovial; osteoarthritis; meta-analysis; synovitis http://www.sciencedirect.com/science/article/pii/S106345841601061X doi:10.1016/j.joca.2016.03.004 doi:10.1016/j.joca.2016.03.004 |
| spellingShingle | ultrasound; synovial; osteoarthritis; meta-analysis; synovitis Sarmanov, Aliya Hall, Michelle C. Moses, Jonathan Doherty, Michael Zhang, Weiya Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies |
| title | Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies |
| title_full | Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies |
| title_fullStr | Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies |
| title_full_unstemmed | Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies |
| title_short | Synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies |
| title_sort | synovial changes detected by ultrasound in people with knee osteoarthritis - a meta-analysis of observational studies |
| topic | ultrasound; synovial; osteoarthritis; meta-analysis; synovitis |
| url | https://eprints.nottingham.ac.uk/32813/ https://eprints.nottingham.ac.uk/32813/ https://eprints.nottingham.ac.uk/32813/ |