Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin
Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflamma...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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American Chemical Society
2014
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| Online Access: | https://eprints.nottingham.ac.uk/32797/ |
| _version_ | 1848794491823063040 |
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| author | Farr, Tracy D. Lai, Chian-Hui Grünstein, Dan Orts-Gil, Guillermo Wang, Cheng-Chung Boehm-Sturm, Philipp Seeberger, Peter H. Harms, Christoph |
| author_facet | Farr, Tracy D. Lai, Chian-Hui Grünstein, Dan Orts-Gil, Guillermo Wang, Cheng-Chung Boehm-Sturm, Philipp Seeberger, Peter H. Harms, Christoph |
| author_sort | Farr, Tracy D. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflammatory proteins E and P selectin. Magnetic resonance imaging revealed that the targeted nanoparticles accumulated in the brain vasculature following acute administration into a clinically relevant animal model of stroke, though increases in selectin expression were observed in both brain hemispheres. Nonfunctionalized naked particles also appear to be a plausible agent to target the ischemic vasculature. The importance of these findings is discussed regarding the potential for translation into the clinic. |
| first_indexed | 2025-11-14T19:17:03Z |
| format | Article |
| id | nottingham-32797 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:17:03Z |
| publishDate | 2014 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-327972020-05-04T16:42:49Z https://eprints.nottingham.ac.uk/32797/ Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin Farr, Tracy D. Lai, Chian-Hui Grünstein, Dan Orts-Gil, Guillermo Wang, Cheng-Chung Boehm-Sturm, Philipp Seeberger, Peter H. Harms, Christoph Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflammatory proteins E and P selectin. Magnetic resonance imaging revealed that the targeted nanoparticles accumulated in the brain vasculature following acute administration into a clinically relevant animal model of stroke, though increases in selectin expression were observed in both brain hemispheres. Nonfunctionalized naked particles also appear to be a plausible agent to target the ischemic vasculature. The importance of these findings is discussed regarding the potential for translation into the clinic. American Chemical Society 2014-02-25 Article PeerReviewed Farr, Tracy D., Lai, Chian-Hui, Grünstein, Dan, Orts-Gil, Guillermo, Wang, Cheng-Chung, Boehm-Sturm, Philipp, Seeberger, Peter H. and Harms, Christoph (2014) Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin. Nano Letters, 14 (4). pp. 2130-2134. ISSN 1530-6992 Glyco-magnetic nanoparticle; MRI; Stroke; Selection; Nano-medicine http://dx.doi.org/10.1021/nl500388h doi:10.1021/nl500388h doi:10.1021/nl500388h |
| spellingShingle | Glyco-magnetic nanoparticle; MRI; Stroke; Selection; Nano-medicine Farr, Tracy D. Lai, Chian-Hui Grünstein, Dan Orts-Gil, Guillermo Wang, Cheng-Chung Boehm-Sturm, Philipp Seeberger, Peter H. Harms, Christoph Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin |
| title | Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin |
| title_full | Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin |
| title_fullStr | Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin |
| title_full_unstemmed | Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin |
| title_short | Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin |
| title_sort | imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin |
| topic | Glyco-magnetic nanoparticle; MRI; Stroke; Selection; Nano-medicine |
| url | https://eprints.nottingham.ac.uk/32797/ https://eprints.nottingham.ac.uk/32797/ https://eprints.nottingham.ac.uk/32797/ |