Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin

Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin

Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflamma...

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Bibliographic Details
Main Authors: Farr, Tracy D., Lai, Chian-Hui, Grünstein, Dan, Orts-Gil, Guillermo, Wang, Cheng-Chung, Boehm-Sturm, Philipp, Seeberger, Peter H., Harms, Christoph
Format: Article
Published: American Chemical Society 2014
Subjects:
Glyco-magnetic nanoparticle; MRI; Stroke; Selection; Nano-medicine
Online Access:https://eprints.nottingham.ac.uk/32797/
Description
Summary:Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflammatory proteins E and P selectin. Magnetic resonance imaging revealed that the targeted nanoparticles accumulated in the brain vasculature following acute administration into a clinically relevant animal model of stroke, though increases in selectin expression were observed in both brain hemispheres. Nonfunctionalized naked particles also appear to be a plausible agent to target the ischemic vasculature. The importance of these findings is discussed regarding the potential for translation into the clinic.

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