Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction

Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction

Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality and, whilst smoking remains the single most important risk factor, COPD risk is heritable. Of 26 independent genomic regions showing association with lung function in genome-wide association studies, e...

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Main Authors: Wain, Louise V., Sayers, Ian, Artigas, María Soler, Portelli, Michael A., Zeggini, Eleftheria, Obeidat, Ma’en, Sin, Don D., Bossé, Yohan, Nickle, David C., Brandsma, Corry-Anke, Malarstig, Anders, Vangjeli, Ciara, Jelingsky, Scott A., John, Sally, Kilty, Iain, McKeever, Tricia M., Shrine, Nick, Cook, James P., Patel, Shrina, Spector, Tim D., Hollox, Edward J., Hall, Ian P., Tobin, Martin D.
Format: Article
Published: Public Library of Science 2014
Online Access:https://eprints.nottingham.ac.uk/32645/

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