Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genot...

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Main Authors:	Artigas, María Soler, Wain, Louise V., Miller, Suzanne, Kheirallah, Abdul Kader, Huffman, Jennifer E., Ntalla, Ioanna, Shrine, Nick, Obeidat, Ma’en, Trochet, Holly, McArdle, Wendy L., Alves, Alexessander Couto, Hui, Jennie, Zhao, Jing Hua, Joshi, Peter K., Teumer, Alexander, Albrecht, Eva, Imboden, Medea, Rawal, Rajesh, Lopez, Lorna M., Marten, Jonathan, Enroth, Stefan, Surakka, Ida, Polasek, Ozren, Lyytikäinen, Leo-Pekka, Granell, Raquel, Hysi, Pirro G., Flexeder, Claudia, Mahajan, Anubha, Beilby, John, Bossé, Yohan, Brandsma, Corry-Anke, Campbell, Harry, Gieger, Christian, Gläser, Sven, González, Juan R., Grallert, Harald, Hammond, Chris J., Harris, Sarah E., Hartikainen, Anna-Liisa, Heliövaara, Markku, Henderson, John, Hocking, Lynne, Horikoshi, Momoko, Hutri-Kähönen, Nina, Ingelsson, Erik, Johansson, Åsa, Kemp, John P., Kolcic, Ivana, Kumar, Ashish, Lind, Lars, Melén, Erik, Musk, Arthur W., Navarro, Pau, Nickle, David C., Padmanabhan, Sandosh, Raitakari, Olli T., Ried, Janina S., Ripatti, Samuli, Schulz, Holger, Scott, Robert A., Sin, Don D., Starr, John M., Deloukas, Panos, Hansell, Anna L., Hubbard, Richard, Jackson, Victoria E., Marchini, Jonathan, Pavord, Ian, Thomson, Neil C., Zeggini, Eleftheria, Viñuela, Ana, Völzke, Henry, Wild, Sarah H., Wright, Alan F., Zemunik, Tatijana, Jarvis, Deborah L., Spector, Tim D., Evans, David M., Lehtimäki, Terho, Vitart, Veronique, Kähönen, Mika, Gyllensten, Ulf, Rudan, Igor, Deary, Ian J., Karrasch, Stefan, Probst-Hensch, Nicole M., Heinrich, Joachim, Stubbe, Beate, Wilson, James F., Wareham, Nicholas J., James, Alan L., Morris, Andrew P., Jarvelin, Marjo-Riitta, Hayward, Caroline, Sayers, Ian, Strachan, David P., Hall, Ian P., Tobin, Martin D.
Format:	Article
Published:	Nature Publishing Group 2015
Online Access:	https://eprints.nottingham.ac.uk/32642/

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author	Artigas, María Soler Wain, Louise V. Miller, Suzanne Kheirallah, Abdul Kader Huffman, Jennifer E. Ntalla, Ioanna Shrine, Nick Obeidat, Ma’en Trochet, Holly McArdle, Wendy L. Alves, Alexessander Couto Hui, Jennie Zhao, Jing Hua Joshi, Peter K. Teumer, Alexander Albrecht, Eva Imboden, Medea Rawal, Rajesh Lopez, Lorna M. Marten, Jonathan Enroth, Stefan Surakka, Ida Polasek, Ozren Lyytikäinen, Leo-Pekka Granell, Raquel Hysi, Pirro G. Flexeder, Claudia Mahajan, Anubha Beilby, John Bossé, Yohan Brandsma, Corry-Anke Campbell, Harry Gieger, Christian Gläser, Sven González, Juan R. Grallert, Harald Hammond, Chris J. Harris, Sarah E. Hartikainen, Anna-Liisa Heliövaara, Markku Henderson, John Hocking, Lynne Horikoshi, Momoko Hutri-Kähönen, Nina Ingelsson, Erik Johansson, Åsa Kemp, John P. Kolcic, Ivana Kumar, Ashish Lind, Lars Melén, Erik Musk, Arthur W. Navarro, Pau Nickle, David C. Padmanabhan, Sandosh Raitakari, Olli T. Ried, Janina S. Ripatti, Samuli Schulz, Holger Scott, Robert A. Sin, Don D. Starr, John M. Deloukas, Panos Hansell, Anna L. Hubbard, Richard Jackson, Victoria E. Marchini, Jonathan Pavord, Ian Thomson, Neil C. Zeggini, Eleftheria Viñuela, Ana Völzke, Henry Wild, Sarah H. Wright, Alan F. Zemunik, Tatijana Jarvis, Deborah L. Spector, Tim D. Evans, David M. Lehtimäki, Terho Vitart, Veronique Kähönen, Mika Gyllensten, Ulf Rudan, Igor Deary, Ian J. Karrasch, Stefan Probst-Hensch, Nicole M. Heinrich, Joachim Stubbe, Beate Wilson, James F. Wareham, Nicholas J. James, Alan L. Morris, Andrew P. Jarvelin, Marjo-Riitta Hayward, Caroline Sayers, Ian Strachan, David P. Hall, Ian P. Tobin, Martin D.
author_facet	Artigas, María Soler Wain, Louise V. Miller, Suzanne Kheirallah, Abdul Kader Huffman, Jennifer E. Ntalla, Ioanna Shrine, Nick Obeidat, Ma’en Trochet, Holly McArdle, Wendy L. Alves, Alexessander Couto Hui, Jennie Zhao, Jing Hua Joshi, Peter K. Teumer, Alexander Albrecht, Eva Imboden, Medea Rawal, Rajesh Lopez, Lorna M. Marten, Jonathan Enroth, Stefan Surakka, Ida Polasek, Ozren Lyytikäinen, Leo-Pekka Granell, Raquel Hysi, Pirro G. Flexeder, Claudia Mahajan, Anubha Beilby, John Bossé, Yohan Brandsma, Corry-Anke Campbell, Harry Gieger, Christian Gläser, Sven González, Juan R. Grallert, Harald Hammond, Chris J. Harris, Sarah E. Hartikainen, Anna-Liisa Heliövaara, Markku Henderson, John Hocking, Lynne Horikoshi, Momoko Hutri-Kähönen, Nina Ingelsson, Erik Johansson, Åsa Kemp, John P. Kolcic, Ivana Kumar, Ashish Lind, Lars Melén, Erik Musk, Arthur W. Navarro, Pau Nickle, David C. Padmanabhan, Sandosh Raitakari, Olli T. Ried, Janina S. Ripatti, Samuli Schulz, Holger Scott, Robert A. Sin, Don D. Starr, John M. Deloukas, Panos Hansell, Anna L. Hubbard, Richard Jackson, Victoria E. Marchini, Jonathan Pavord, Ian Thomson, Neil C. Zeggini, Eleftheria Viñuela, Ana Völzke, Henry Wild, Sarah H. Wright, Alan F. Zemunik, Tatijana Jarvis, Deborah L. Spector, Tim D. Evans, David M. Lehtimäki, Terho Vitart, Veronique Kähönen, Mika Gyllensten, Ulf Rudan, Igor Deary, Ian J. Karrasch, Stefan Probst-Hensch, Nicole M. Heinrich, Joachim Stubbe, Beate Wilson, James F. Wareham, Nicholas J. James, Alan L. Morris, Andrew P. Jarvelin, Marjo-Riitta Hayward, Caroline Sayers, Ian Strachan, David P. Hall, Ian P. Tobin, Martin D.
author_sort	Artigas, María Soler
building	Nottingham Research Data Repository
collection	Online Access
description	Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
first_indexed	2025-11-14T19:16:29Z
format	Article
id	nottingham-32642
institution	University of Nottingham Malaysia Campus
institution_category	Local University
last_indexed	2025-11-14T19:16:29Z
publishDate	2015
publisher	Nature Publishing Group
recordtype	eprints
repository_type	Digital Repository
spelling	nottingham-326422024-08-15T15:32:27Z https://eprints.nottingham.ac.uk/32642/ Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation Artigas, María Soler Wain, Louise V. Miller, Suzanne Kheirallah, Abdul Kader Huffman, Jennifer E. Ntalla, Ioanna Shrine, Nick Obeidat, Ma’en Trochet, Holly McArdle, Wendy L. Alves, Alexessander Couto Hui, Jennie Zhao, Jing Hua Joshi, Peter K. Teumer, Alexander Albrecht, Eva Imboden, Medea Rawal, Rajesh Lopez, Lorna M. Marten, Jonathan Enroth, Stefan Surakka, Ida Polasek, Ozren Lyytikäinen, Leo-Pekka Granell, Raquel Hysi, Pirro G. Flexeder, Claudia Mahajan, Anubha Beilby, John Bossé, Yohan Brandsma, Corry-Anke Campbell, Harry Gieger, Christian Gläser, Sven González, Juan R. Grallert, Harald Hammond, Chris J. Harris, Sarah E. Hartikainen, Anna-Liisa Heliövaara, Markku Henderson, John Hocking, Lynne Horikoshi, Momoko Hutri-Kähönen, Nina Ingelsson, Erik Johansson, Åsa Kemp, John P. Kolcic, Ivana Kumar, Ashish Lind, Lars Melén, Erik Musk, Arthur W. Navarro, Pau Nickle, David C. Padmanabhan, Sandosh Raitakari, Olli T. Ried, Janina S. Ripatti, Samuli Schulz, Holger Scott, Robert A. Sin, Don D. Starr, John M. Deloukas, Panos Hansell, Anna L. Hubbard, Richard Jackson, Victoria E. Marchini, Jonathan Pavord, Ian Thomson, Neil C. Zeggini, Eleftheria Viñuela, Ana Völzke, Henry Wild, Sarah H. Wright, Alan F. Zemunik, Tatijana Jarvis, Deborah L. Spector, Tim D. Evans, David M. Lehtimäki, Terho Vitart, Veronique Kähönen, Mika Gyllensten, Ulf Rudan, Igor Deary, Ian J. Karrasch, Stefan Probst-Hensch, Nicole M. Heinrich, Joachim Stubbe, Beate Wilson, James F. Wareham, Nicholas J. James, Alan L. Morris, Andrew P. Jarvelin, Marjo-Riitta Hayward, Caroline Sayers, Ian Strachan, David P. Hall, Ian P. Tobin, Martin D. Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered. Nature Publishing Group 2015-12 Article PeerReviewed Artigas, María Soler, Wain, Louise V., Miller, Suzanne, Kheirallah, Abdul Kader, Huffman, Jennifer E., Ntalla, Ioanna, Shrine, Nick, Obeidat, Ma’en, Trochet, Holly, McArdle, Wendy L., Alves, Alexessander Couto, Hui, Jennie, Zhao, Jing Hua, Joshi, Peter K., Teumer, Alexander, Albrecht, Eva, Imboden, Medea, Rawal, Rajesh, Lopez, Lorna M., Marten, Jonathan, Enroth, Stefan, Surakka, Ida, Polasek, Ozren, Lyytikäinen, Leo-Pekka, Granell, Raquel, Hysi, Pirro G., Flexeder, Claudia, Mahajan, Anubha, Beilby, John, Bossé, Yohan, Brandsma, Corry-Anke, Campbell, Harry, Gieger, Christian, Gläser, Sven, González, Juan R., Grallert, Harald, Hammond, Chris J., Harris, Sarah E., Hartikainen, Anna-Liisa, Heliövaara, Markku, Henderson, John, Hocking, Lynne, Horikoshi, Momoko, Hutri-Kähönen, Nina, Ingelsson, Erik, Johansson, Åsa, Kemp, John P., Kolcic, Ivana, Kumar, Ashish, Lind, Lars, Melén, Erik, Musk, Arthur W., Navarro, Pau, Nickle, David C., Padmanabhan, Sandosh, Raitakari, Olli T., Ried, Janina S., Ripatti, Samuli, Schulz, Holger, Scott, Robert A., Sin, Don D., Starr, John M., Deloukas, Panos, Hansell, Anna L., Hubbard, Richard, Jackson, Victoria E., Marchini, Jonathan, Pavord, Ian, Thomson, Neil C., Zeggini, Eleftheria, Viñuela, Ana, Völzke, Henry, Wild, Sarah H., Wright, Alan F., Zemunik, Tatijana, Jarvis, Deborah L., Spector, Tim D., Evans, David M., Lehtimäki, Terho, Vitart, Veronique, Kähönen, Mika, Gyllensten, Ulf, Rudan, Igor, Deary, Ian J., Karrasch, Stefan, Probst-Hensch, Nicole M., Heinrich, Joachim, Stubbe, Beate, Wilson, James F., Wareham, Nicholas J., James, Alan L., Morris, Andrew P., Jarvelin, Marjo-Riitta, Hayward, Caroline, Sayers, Ian, Strachan, David P., Hall, Ian P. and Tobin, Martin D. (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6 . 8658/1-8658/12. ISSN 2041-1723 http://dx.doi.org/10.1038/ncomms9658 doi:10.1038/ncomms9658 doi:10.1038/ncomms9658
spellingShingle	Artigas, María Soler Wain, Louise V. Miller, Suzanne Kheirallah, Abdul Kader Huffman, Jennifer E. Ntalla, Ioanna Shrine, Nick Obeidat, Ma’en Trochet, Holly McArdle, Wendy L. Alves, Alexessander Couto Hui, Jennie Zhao, Jing Hua Joshi, Peter K. Teumer, Alexander Albrecht, Eva Imboden, Medea Rawal, Rajesh Lopez, Lorna M. Marten, Jonathan Enroth, Stefan Surakka, Ida Polasek, Ozren Lyytikäinen, Leo-Pekka Granell, Raquel Hysi, Pirro G. Flexeder, Claudia Mahajan, Anubha Beilby, John Bossé, Yohan Brandsma, Corry-Anke Campbell, Harry Gieger, Christian Gläser, Sven González, Juan R. Grallert, Harald Hammond, Chris J. Harris, Sarah E. Hartikainen, Anna-Liisa Heliövaara, Markku Henderson, John Hocking, Lynne Horikoshi, Momoko Hutri-Kähönen, Nina Ingelsson, Erik Johansson, Åsa Kemp, John P. Kolcic, Ivana Kumar, Ashish Lind, Lars Melén, Erik Musk, Arthur W. Navarro, Pau Nickle, David C. Padmanabhan, Sandosh Raitakari, Olli T. Ried, Janina S. Ripatti, Samuli Schulz, Holger Scott, Robert A. Sin, Don D. Starr, John M. Deloukas, Panos Hansell, Anna L. Hubbard, Richard Jackson, Victoria E. Marchini, Jonathan Pavord, Ian Thomson, Neil C. Zeggini, Eleftheria Viñuela, Ana Völzke, Henry Wild, Sarah H. Wright, Alan F. Zemunik, Tatijana Jarvis, Deborah L. Spector, Tim D. Evans, David M. Lehtimäki, Terho Vitart, Veronique Kähönen, Mika Gyllensten, Ulf Rudan, Igor Deary, Ian J. Karrasch, Stefan Probst-Hensch, Nicole M. Heinrich, Joachim Stubbe, Beate Wilson, James F. Wareham, Nicholas J. James, Alan L. Morris, Andrew P. Jarvelin, Marjo-Riitta Hayward, Caroline Sayers, Ian Strachan, David P. Hall, Ian P. Tobin, Martin D. Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
title	Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
title_full	Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
title_fullStr	Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
title_full_unstemmed	Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
title_short	Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
title_sort	sixteen new lung function signals identified through 1000 genomes project reference panel imputation
url	https://eprints.nottingham.ac.uk/32642/ https://eprints.nottingham.ac.uk/32642/ https://eprints.nottingham.ac.uk/32642/

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

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