The impact of azithromycin therapy on the airway microbiota in asthma
There is interest in the use of macrolide antibiotics in asthma. Macrolides have been shown to improve airway hyperresponsiveness (AHR) and measures of airway inflammation.The degree of AHR may relate to the microbiota present in the airways, with a recent study reporting that patients with asthma w...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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BMJ Publishing Group
2014
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| Online Access: | https://eprints.nottingham.ac.uk/32641/ |
| _version_ | 1848794455865294848 |
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| author | Slater, Mariel Rivett, Damian W. Williams, Lisa Martin, Matthew Harrison, Timothy W. Sayers, Ian Bruce, Kenneth D. Shaw, Dominick E. |
| author_facet | Slater, Mariel Rivett, Damian W. Williams, Lisa Martin, Matthew Harrison, Timothy W. Sayers, Ian Bruce, Kenneth D. Shaw, Dominick E. |
| author_sort | Slater, Mariel |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | There is interest in the use of macrolide antibiotics in asthma. Macrolides have been shown to improve airway hyperresponsiveness (AHR) and measures of airway inflammation.The degree of AHR may relate to the microbiota present in the airways, with a recent study reporting that patients with asthma with a significant improvement in AHR following treatment with clarithromycin had a higher bacterial diversity prior to treatment. To our knowledge, the impact on the asthmatic airway microbiota of an antibiotic has not been reported and we therefore set out to establish if macrolide therapy was associated with a change in airway microbiota in asthma. |
| first_indexed | 2025-11-14T19:16:28Z |
| format | Article |
| id | nottingham-32641 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:16:28Z |
| publishDate | 2014 |
| publisher | BMJ Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-326412020-05-04T20:14:09Z https://eprints.nottingham.ac.uk/32641/ The impact of azithromycin therapy on the airway microbiota in asthma Slater, Mariel Rivett, Damian W. Williams, Lisa Martin, Matthew Harrison, Timothy W. Sayers, Ian Bruce, Kenneth D. Shaw, Dominick E. There is interest in the use of macrolide antibiotics in asthma. Macrolides have been shown to improve airway hyperresponsiveness (AHR) and measures of airway inflammation.The degree of AHR may relate to the microbiota present in the airways, with a recent study reporting that patients with asthma with a significant improvement in AHR following treatment with clarithromycin had a higher bacterial diversity prior to treatment. To our knowledge, the impact on the asthmatic airway microbiota of an antibiotic has not been reported and we therefore set out to establish if macrolide therapy was associated with a change in airway microbiota in asthma. BMJ Publishing Group 2014-07 Article PeerReviewed Slater, Mariel, Rivett, Damian W., Williams, Lisa, Martin, Matthew, Harrison, Timothy W., Sayers, Ian, Bruce, Kenneth D. and Shaw, Dominick E. (2014) The impact of azithromycin therapy on the airway microbiota in asthma. Thorax, 69 (7). pp. 673-674. ISSN 1468-3296 http://dx.doi.org/10.1136/thoraxjnl-2013-204517 doi:10.1136/thoraxjnl-2013-204517 doi:10.1136/thoraxjnl-2013-204517 |
| spellingShingle | Slater, Mariel Rivett, Damian W. Williams, Lisa Martin, Matthew Harrison, Timothy W. Sayers, Ian Bruce, Kenneth D. Shaw, Dominick E. The impact of azithromycin therapy on the airway microbiota in asthma |
| title | The impact of azithromycin therapy on the airway microbiota in asthma |
| title_full | The impact of azithromycin therapy on the airway microbiota in asthma |
| title_fullStr | The impact of azithromycin therapy on the airway microbiota in asthma |
| title_full_unstemmed | The impact of azithromycin therapy on the airway microbiota in asthma |
| title_short | The impact of azithromycin therapy on the airway microbiota in asthma |
| title_sort | impact of azithromycin therapy on the airway microbiota in asthma |
| url | https://eprints.nottingham.ac.uk/32641/ https://eprints.nottingham.ac.uk/32641/ https://eprints.nottingham.ac.uk/32641/ |