Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels

QR Code

Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels

The soluble cleaved urokinase plasminogen activator receptor (scuPAR) is a circulating protein detected in multiple diseases, including various cancers, cardiovascular disease, and kidney disease, where elevated levels of scuPAR have been associated with worsening prognosis and increased disease agg...

Full description

Bibliographic Details
Main Authors:	Portelli, Michael A., Siedlinski, Mateusz, Stewart, Ceri E., Postma, Dirkje S., Nieuwenhuis, Maartje A., Vonk, Judith M., Nurnberg, Peter, Altmuller, Janine, Moffatt, M.F., Wardlaw, Andrew J., Parker, Stuart G., Connolly, Martin J., Koppelman, Gerard H., Sayers, Ian
Format:	Article
Published:	Federation of American Society of Experimental Biology 2014
Subjects:	GWAS Proteolysis Respiratory disease HBECs Cellular proliferation Wound repair
Online Access:	https://eprints.nottingham.ac.uk/32639/

Similar Items

Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels
by: Portelli, Michael, et al.
Published: (2014)

Defining novel targets of the plant N-degron pathways
by: Taylor, Leonard
Published: (2023)

Novel insight into uPAR function in the bronchial epithelium in asthma using functional genomics
by: Bhaker, Sangita
Published: (2017)

The role and regulation of the urokinase receptor in asthma and COPD
by: Portelli, Michael A.
Published: (2013)

Response
by: Sayers, Ian, et al.
Published: (2015)

Enhanced waterlogging tolerance in barley by manipulation of expression of the N-end rule pathway E3 ligase PROTEOLYSIS6
by: Mendiondo, Guillermina M., et al.
Published: (2015)

Germline determinants of the immune response in Asian breast cancer
by: Yap, Beverley Ling Shan
Published: (2025)

Characterisation of PRT1, an E3 Ligase of the N-end Rule Pathway in Arabidopsis thaliana
by: Till, Christopher John
Published: (2019)

Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes
by: Murton, Andrew J., et al.
Published: (2016)

The influence of peri-conception and first trimester dietary restriction of protein in cattle on meat quality traits of entire male progeny
by: Alvarenga, Tharcilla I.R.C., et al.
Published: (2016)

α-Amidobenzylboronates and β-Ketobenzylboronates as Inhibitors of Plasma Kallikrein
by: Allison, Matthew
Published: (2024)

Complementary approaches to analyse genetic data in late onset Alzheimer's disease (LOAD)
by: Shi, Hui
Published: (2012)

Penyediaan graf piawai tisu kallikrein untuk jabatan fisiologi
by: Bakar, Asiah Abu, et al.
Published: (2000)

Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identiﬁes a severe, nonatopic subset of patients
by: Portelli, Michael A., et al.
Published: (2016)

Identification of candidate genes for calcium and magnesium accumulation in Brassica napus L. by association genetics
by: Alcock, T.D., et al.
Published: (2017)

Studies On Kallikrein-kinin System In Normotensive And Hypertensive Rats With And Without Diabetes
by: Kesavarao, Uma
Published: (1995)

Kallikrein-kinin system in human fetoplacental tissues in pregnancy -induced hypertension
by: Larmie, E.T., et al.
Published: (2004)

Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma
by: Ierodiakonou, Despo, et al.
Published: (2016)

Genetic diversity analysis and trait phenotyping for drought tolerance in Amaranth (Amaranthus spp) Germplasm
by: Jamalluddin, Norain
Published: (2020)

RFLP Markers and their relationship with a QTL in sheep
by: Mukberjee, T.K., et al.
Published: (2006)

Plant hormones associated with increasing grain number and yield potential in wheat (Triticum aestivum L.) and their genetic regulation
by: Love, Bethany
Published: (2022)

From start to finish: amino-terminal protein modifications as degredation signals in plant
by: Gibbs, Daniel J., et al.
Published: (2016)

From start to finish: amino-terminal protein modifications as degradation signals in plants
by: Gibbs, Daniel J., et al.
Published: (2016)

The Cys-Arg/N-end rule pathway is a general sensor of abiotic stress in flowering plants
by: Vicente, Jorge, et al.
Published: (2017)

Identification of QTL for resistance and susceptibility to Stagonospora meliloti in autotetraploid lucerne
by: Musial, J., et al.
Published: (2007)

A global barley panel revealing genomic signatures of breeding in modern Australian cultivars.
by: Hill, Camilla Beate, et al.
Published: (2021)

Gene-set association and epistatic analyses reveal complex gene interaction networks affecting flowering time in a worldwide barley collection
by: He, Tianhua, et al.
Published: (2019)

Genetic analysis of physiological traits to increase grain partitioning in high biomass cultivars in wheat (Triticum aestivum L.)
by: Sierra-Gonzalez, Aleyda
Published: (2020)

Phenotyping pipeline reveals major seedling root growth QTL in hexaploid wheat
by: Atkinson, Jonathan A., et al.
Published: (2015)

Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin
by: Kehinde, Samuel Abiodun, et al.
Published: (2024)

Out of Africa: Exploring the African germplasm for the sustainable production of rice in future climates
by: Cowling, Sophie
Published: (2022)

Yield-Related QTL Clusters and the Potential Candidate Genes in Two Wheat DH Populations
by: Zhang, Jingjuan, et al.
Published: (2021)

Genetic Linkage and Quantitative Trait Loci (QTL) Mapping in Hevea-Latex Timber Clones
by: Atan, Safiah
Published: (2011)

Characterization of the PGK2 associated microsatellite S0719 on SSC7 suitable for parentage and QTL diagnosis
by: Chen, Kefei, et al.
Published: (2006)

Genetic dissection of rice blast resistance by QTL mapping approach using an F3 population
by: Ashkani, Sadegh, et al.
Published: (2013)

Mapping of the quantitative trait locus (QTL) conferring partial resistance to rice leaf blast disease
by: Ashkani, Sadegh, et al.
Published: (2013)

A cross-species gene expression marker-based genetic map and QTL analysis in bambara groundnut
by: Chai, Hui, et al.
Published: (2017)

Identification of QTL for reaction to three races of Colletotrichum trifolii and further analysis of inheritance of resistance in autotetraploid lucerne
by: Mackie, J., et al.
Published: (2007)

THE MORPHO-PHYSIOLOGICAL EFFECT OF DROUGHT AND DROUGHT QTL ANALYSIS ON BAMBARA GROUNDNUT (VIGNA SUBTERRANEA(L) VERDC)
by: KRISHNAMOORTHY, MAHALETCHUMY
Published: (2020)

The morpho-physiological effect of drought and drought QTL analysis on Bambara Groundnut (Vigna Subterranean (L) Verdc)
by: Krishnamoorthy, Mahaletchumy
Published: (2020)