Genome-wide association analysis identifies six new loci associated with forced vital capacity

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 addit...

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Main Authors:	Loth, Daan W., Artigas, María Soler, Gharib, Sina A., Wain, Louise V., Franceschini, Nora, Koch, Beate, Pottinger, Tess D., Smith, Albert Vernon, Duan, Qing, Oldmeadow, Chris, Lee, Mi Kyeong, Strachan, David P., James, Alan L., Huffman, Jennifer E., Vitart, Veronique, Ramasamy, Adaikalavan, Wareham, Nicholas J., Kaprio, Jaakko, Wang, Xin-Qun, Trochet, Holly, Kähönen, Mika, Flexeder, Claudia, Albrecht, Eva, Lopez, Lorna M., de Jong, Kim, Thyagarajan, Bharat, Alves, Alexessander Couto, Enroth, Stefan, Omenaas, Ernst, Joshi, Peter K., Fall, Tove, Viñuela, Ana, Launer, Lenore J., Loehr, Laura R., Fornage, Myriam, Li, Guo, Wilk, Jemma B., Tang, Wenbo, Manichaikul, Ani, Lahousse, Lies, Harris, Tamara B., North, Kari E., Rudnicka, Alicja R., Hui, Jennie, Gu, Xiangjun, Lumley, Thomas, Wright, Alan F., Hastie, Nicholas D., Campbell, Susan, Kumar, Rajesh, Pin, Isabelle, Scott, Robert A., Pietiläinen, Kirsi H., Surakka, Ida, Liu, Yongmei, Holliday, Elizabeth G., Schulz, Holger, Heinrich, Joachim, Davies, Gail, Vonk, Judith M., Wojczynski, Mary, Pouta, Anneli, Johansson, Åsa, Wild, Sarah H., Ingelsson, Erik, Rivadeneira, Fernando, Völzke, Henry, Hysi, Pirro G., Eiriksdottir, Gudny, Morrison, Alanna C., Rotter, Jerome I., Gao, Wei, Postma, Dirkje S., White, Wendy B., Rich, Stephen S., Hofman, Albert, Aspelund, Thor, Couper, David, Smith, Lewis J., Psaty, Bruce M., Lohman, Kurt, Burchard, Esteban G., Uitterlinden, André G., Garcia, Melissa, Joubert, Bonnie R., McArdle, Wendy L., Musk, A Bill, Hansel, Nadia, Heckbert, Susan R., Zgaga, Lina, van Meurs, Joyce B.J., Navarro, Pau, Rudan, Igor, Oh, Yeon-Mok, Redline, Susan, Jarvis, Deborah L., Zhao, Jing Hua, Rantanen, Taina, O'Connor, George T., Ripatti, Samuli, Scott, Rodney J., Karrasch, Stefan, Grallert, Harald, Gaddis, Nathan C., Starr, John M., Wijmenga, Cisca, Minster, Ryan L., Lederer, David J., Pekkanen, Juha, Gyllensten, Ulf, Campbell, Harry, Morris, Andrew P., Gläser, Sven, Hammond, Christopher J., Burkart, Kristin M, Beilby, John, Kritchevsky, Stephen B., Gudnason, Vilmundur, Hancock, Dana B., Williams, O Dale, Polasek, Ozren, Zemunik, Tatijana, Kolcic, Ivana, Petrini, Marcy F., Wjst, Matthias, Kim, Woo Jin, Porteous, David J., Smith, Blair H., Viljanen, Anne, Heliövaara, Markku, Attia, John R., Sayers, Ian, Hampel, Regina, Gieger, Christian, Deary, Ian J, Boezen, H. Marike, Newman, Anne, Jarvelin, Marjo-Riitta, Wilson, James F, Lind, Lars, Stricker, Bruno H., Teumer, Alexander, Spector, Timothy D., Melén, Erik, Peters, Marjolein J., Lange, Leslie A., Barr, R. Graham, Bracke, Ken R., Verhamme, Fien M., Sung, Joohon, Hiemstra, Pieter S., Cassano, Patricia A., Sood, Akshay, Hayward, Caroline, Dupuis, Josée, Hall, Ian P., Brusselle, Guy G., Tobin, Martin D., London, Stephanie J.
Format:	Article
Published:	Nature Publishing Group 2014
Subjects:	Genetics research Genome-wide association studies Population genetics Respiratory tract diseases
Online Access:	https://eprints.nottingham.ac.uk/32637/

_version_	1848794454590226432
author	Loth, Daan W. Artigas, María Soler Gharib, Sina A. Wain, Louise V. Franceschini, Nora Koch, Beate Pottinger, Tess D. Smith, Albert Vernon Duan, Qing Oldmeadow, Chris Lee, Mi Kyeong Strachan, David P. James, Alan L. Huffman, Jennifer E. Vitart, Veronique Ramasamy, Adaikalavan Wareham, Nicholas J. Kaprio, Jaakko Wang, Xin-Qun Trochet, Holly Kähönen, Mika Flexeder, Claudia Albrecht, Eva Lopez, Lorna M. de Jong, Kim Thyagarajan, Bharat Alves, Alexessander Couto Enroth, Stefan Omenaas, Ernst Joshi, Peter K. Fall, Tove Viñuela, Ana Launer, Lenore J. Loehr, Laura R. Fornage, Myriam Li, Guo Wilk, Jemma B. Tang, Wenbo Manichaikul, Ani Lahousse, Lies Harris, Tamara B. North, Kari E. Rudnicka, Alicja R. Hui, Jennie Gu, Xiangjun Lumley, Thomas Wright, Alan F. Hastie, Nicholas D. Campbell, Susan Kumar, Rajesh Pin, Isabelle Scott, Robert A. Pietiläinen, Kirsi H. Surakka, Ida Liu, Yongmei Holliday, Elizabeth G. Schulz, Holger Heinrich, Joachim Davies, Gail Vonk, Judith M. Wojczynski, Mary Pouta, Anneli Johansson, Åsa Wild, Sarah H. Ingelsson, Erik Rivadeneira, Fernando Völzke, Henry Hysi, Pirro G. Eiriksdottir, Gudny Morrison, Alanna C. Rotter, Jerome I. Gao, Wei Postma, Dirkje S. White, Wendy B. Rich, Stephen S. Hofman, Albert Aspelund, Thor Couper, David Smith, Lewis J. Psaty, Bruce M. Lohman, Kurt Burchard, Esteban G. Uitterlinden, André G. Garcia, Melissa Joubert, Bonnie R. McArdle, Wendy L. Musk, A Bill Hansel, Nadia Heckbert, Susan R. Zgaga, Lina van Meurs, Joyce B.J. Navarro, Pau Rudan, Igor Oh, Yeon-Mok Redline, Susan Jarvis, Deborah L. Zhao, Jing Hua Rantanen, Taina O'Connor, George T. Ripatti, Samuli Scott, Rodney J. Karrasch, Stefan Grallert, Harald Gaddis, Nathan C. Starr, John M. Wijmenga, Cisca Minster, Ryan L. Lederer, David J. Pekkanen, Juha Gyllensten, Ulf Campbell, Harry Morris, Andrew P. Gläser, Sven Hammond, Christopher J. Burkart, Kristin M Beilby, John Kritchevsky, Stephen B. Gudnason, Vilmundur Hancock, Dana B. Williams, O Dale Polasek, Ozren Zemunik, Tatijana Kolcic, Ivana Petrini, Marcy F. Wjst, Matthias Kim, Woo Jin Porteous, David J. Smith, Blair H. Viljanen, Anne Heliövaara, Markku Attia, John R. Sayers, Ian Hampel, Regina Gieger, Christian Deary, Ian J Boezen, H. Marike Newman, Anne Jarvelin, Marjo-Riitta Wilson, James F Lind, Lars Stricker, Bruno H. Teumer, Alexander Spector, Timothy D. Melén, Erik Peters, Marjolein J. Lange, Leslie A. Barr, R. Graham Bracke, Ken R. Verhamme, Fien M. Sung, Joohon Hiemstra, Pieter S. Cassano, Patricia A. Sood, Akshay Hayward, Caroline Dupuis, Josée Hall, Ian P. Brusselle, Guy G. Tobin, Martin D. London, Stephanie J.
author_facet	Loth, Daan W. Artigas, María Soler Gharib, Sina A. Wain, Louise V. Franceschini, Nora Koch, Beate Pottinger, Tess D. Smith, Albert Vernon Duan, Qing Oldmeadow, Chris Lee, Mi Kyeong Strachan, David P. James, Alan L. Huffman, Jennifer E. Vitart, Veronique Ramasamy, Adaikalavan Wareham, Nicholas J. Kaprio, Jaakko Wang, Xin-Qun Trochet, Holly Kähönen, Mika Flexeder, Claudia Albrecht, Eva Lopez, Lorna M. de Jong, Kim Thyagarajan, Bharat Alves, Alexessander Couto Enroth, Stefan Omenaas, Ernst Joshi, Peter K. Fall, Tove Viñuela, Ana Launer, Lenore J. Loehr, Laura R. Fornage, Myriam Li, Guo Wilk, Jemma B. Tang, Wenbo Manichaikul, Ani Lahousse, Lies Harris, Tamara B. North, Kari E. Rudnicka, Alicja R. Hui, Jennie Gu, Xiangjun Lumley, Thomas Wright, Alan F. Hastie, Nicholas D. Campbell, Susan Kumar, Rajesh Pin, Isabelle Scott, Robert A. Pietiläinen, Kirsi H. Surakka, Ida Liu, Yongmei Holliday, Elizabeth G. Schulz, Holger Heinrich, Joachim Davies, Gail Vonk, Judith M. Wojczynski, Mary Pouta, Anneli Johansson, Åsa Wild, Sarah H. Ingelsson, Erik Rivadeneira, Fernando Völzke, Henry Hysi, Pirro G. Eiriksdottir, Gudny Morrison, Alanna C. Rotter, Jerome I. Gao, Wei Postma, Dirkje S. White, Wendy B. Rich, Stephen S. Hofman, Albert Aspelund, Thor Couper, David Smith, Lewis J. Psaty, Bruce M. Lohman, Kurt Burchard, Esteban G. Uitterlinden, André G. Garcia, Melissa Joubert, Bonnie R. McArdle, Wendy L. Musk, A Bill Hansel, Nadia Heckbert, Susan R. Zgaga, Lina van Meurs, Joyce B.J. Navarro, Pau Rudan, Igor Oh, Yeon-Mok Redline, Susan Jarvis, Deborah L. Zhao, Jing Hua Rantanen, Taina O'Connor, George T. Ripatti, Samuli Scott, Rodney J. Karrasch, Stefan Grallert, Harald Gaddis, Nathan C. Starr, John M. Wijmenga, Cisca Minster, Ryan L. Lederer, David J. Pekkanen, Juha Gyllensten, Ulf Campbell, Harry Morris, Andrew P. Gläser, Sven Hammond, Christopher J. Burkart, Kristin M Beilby, John Kritchevsky, Stephen B. Gudnason, Vilmundur Hancock, Dana B. Williams, O Dale Polasek, Ozren Zemunik, Tatijana Kolcic, Ivana Petrini, Marcy F. Wjst, Matthias Kim, Woo Jin Porteous, David J. Smith, Blair H. Viljanen, Anne Heliövaara, Markku Attia, John R. Sayers, Ian Hampel, Regina Gieger, Christian Deary, Ian J Boezen, H. Marike Newman, Anne Jarvelin, Marjo-Riitta Wilson, James F Lind, Lars Stricker, Bruno H. Teumer, Alexander Spector, Timothy D. Melén, Erik Peters, Marjolein J. Lange, Leslie A. Barr, R. Graham Bracke, Ken R. Verhamme, Fien M. Sung, Joohon Hiemstra, Pieter S. Cassano, Patricia A. Sood, Akshay Hayward, Caroline Dupuis, Josée Hall, Ian P. Brusselle, Guy G. Tobin, Martin D. London, Stephanie J.
author_sort	Loth, Daan W.
building	Nottingham Research Data Repository
collection	Online Access
description	Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10−8) with FVC in or near EFEMP1, BMP6, MIR129-2–HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.
first_indexed	2025-11-14T19:16:27Z
format	Article
id	nottingham-32637
institution	University of Nottingham Malaysia Campus
institution_category	Local University
last_indexed	2025-11-14T19:16:27Z
publishDate	2014
publisher	Nature Publishing Group
recordtype	eprints
repository_type	Digital Repository
spelling	nottingham-326372020-05-04T20:13:58Z https://eprints.nottingham.ac.uk/32637/ Genome-wide association analysis identifies six new loci associated with forced vital capacity Loth, Daan W. Artigas, María Soler Gharib, Sina A. Wain, Louise V. Franceschini, Nora Koch, Beate Pottinger, Tess D. Smith, Albert Vernon Duan, Qing Oldmeadow, Chris Lee, Mi Kyeong Strachan, David P. James, Alan L. Huffman, Jennifer E. Vitart, Veronique Ramasamy, Adaikalavan Wareham, Nicholas J. Kaprio, Jaakko Wang, Xin-Qun Trochet, Holly Kähönen, Mika Flexeder, Claudia Albrecht, Eva Lopez, Lorna M. de Jong, Kim Thyagarajan, Bharat Alves, Alexessander Couto Enroth, Stefan Omenaas, Ernst Joshi, Peter K. Fall, Tove Viñuela, Ana Launer, Lenore J. Loehr, Laura R. Fornage, Myriam Li, Guo Wilk, Jemma B. Tang, Wenbo Manichaikul, Ani Lahousse, Lies Harris, Tamara B. North, Kari E. Rudnicka, Alicja R. Hui, Jennie Gu, Xiangjun Lumley, Thomas Wright, Alan F. Hastie, Nicholas D. Campbell, Susan Kumar, Rajesh Pin, Isabelle Scott, Robert A. Pietiläinen, Kirsi H. Surakka, Ida Liu, Yongmei Holliday, Elizabeth G. Schulz, Holger Heinrich, Joachim Davies, Gail Vonk, Judith M. Wojczynski, Mary Pouta, Anneli Johansson, Åsa Wild, Sarah H. Ingelsson, Erik Rivadeneira, Fernando Völzke, Henry Hysi, Pirro G. Eiriksdottir, Gudny Morrison, Alanna C. Rotter, Jerome I. Gao, Wei Postma, Dirkje S. White, Wendy B. Rich, Stephen S. Hofman, Albert Aspelund, Thor Couper, David Smith, Lewis J. Psaty, Bruce M. Lohman, Kurt Burchard, Esteban G. Uitterlinden, André G. Garcia, Melissa Joubert, Bonnie R. McArdle, Wendy L. Musk, A Bill Hansel, Nadia Heckbert, Susan R. Zgaga, Lina van Meurs, Joyce B.J. Navarro, Pau Rudan, Igor Oh, Yeon-Mok Redline, Susan Jarvis, Deborah L. Zhao, Jing Hua Rantanen, Taina O'Connor, George T. Ripatti, Samuli Scott, Rodney J. Karrasch, Stefan Grallert, Harald Gaddis, Nathan C. Starr, John M. Wijmenga, Cisca Minster, Ryan L. Lederer, David J. Pekkanen, Juha Gyllensten, Ulf Campbell, Harry Morris, Andrew P. Gläser, Sven Hammond, Christopher J. Burkart, Kristin M Beilby, John Kritchevsky, Stephen B. Gudnason, Vilmundur Hancock, Dana B. Williams, O Dale Polasek, Ozren Zemunik, Tatijana Kolcic, Ivana Petrini, Marcy F. Wjst, Matthias Kim, Woo Jin Porteous, David J. Smith, Blair H. Viljanen, Anne Heliövaara, Markku Attia, John R. Sayers, Ian Hampel, Regina Gieger, Christian Deary, Ian J Boezen, H. Marike Newman, Anne Jarvelin, Marjo-Riitta Wilson, James F Lind, Lars Stricker, Bruno H. Teumer, Alexander Spector, Timothy D. Melén, Erik Peters, Marjolein J. Lange, Leslie A. Barr, R. Graham Bracke, Ken R. Verhamme, Fien M. Sung, Joohon Hiemstra, Pieter S. Cassano, Patricia A. Sood, Akshay Hayward, Caroline Dupuis, Josée Hall, Ian P. Brusselle, Guy G. Tobin, Martin D. London, Stephanie J. Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10−8) with FVC in or near EFEMP1, BMP6, MIR129-2–HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease. Nature Publishing Group 2014-07 Article PeerReviewed Loth, Daan W., Artigas, María Soler, Gharib, Sina A., Wain, Louise V., Franceschini, Nora, Koch, Beate, Pottinger, Tess D., Smith, Albert Vernon, Duan, Qing, Oldmeadow, Chris, Lee, Mi Kyeong, Strachan, David P., James, Alan L., Huffman, Jennifer E., Vitart, Veronique, Ramasamy, Adaikalavan, Wareham, Nicholas J., Kaprio, Jaakko, Wang, Xin-Qun, Trochet, Holly, Kähönen, Mika, Flexeder, Claudia, Albrecht, Eva, Lopez, Lorna M., de Jong, Kim, Thyagarajan, Bharat, Alves, Alexessander Couto, Enroth, Stefan, Omenaas, Ernst, Joshi, Peter K., Fall, Tove, Viñuela, Ana, Launer, Lenore J., Loehr, Laura R., Fornage, Myriam, Li, Guo, Wilk, Jemma B., Tang, Wenbo, Manichaikul, Ani, Lahousse, Lies, Harris, Tamara B., North, Kari E., Rudnicka, Alicja R., Hui, Jennie, Gu, Xiangjun, Lumley, Thomas, Wright, Alan F., Hastie, Nicholas D., Campbell, Susan, Kumar, Rajesh, Pin, Isabelle, Scott, Robert A., Pietiläinen, Kirsi H., Surakka, Ida, Liu, Yongmei, Holliday, Elizabeth G., Schulz, Holger, Heinrich, Joachim, Davies, Gail, Vonk, Judith M., Wojczynski, Mary, Pouta, Anneli, Johansson, Åsa, Wild, Sarah H., Ingelsson, Erik, Rivadeneira, Fernando, Völzke, Henry, Hysi, Pirro G., Eiriksdottir, Gudny, Morrison, Alanna C., Rotter, Jerome I., Gao, Wei, Postma, Dirkje S., White, Wendy B., Rich, Stephen S., Hofman, Albert, Aspelund, Thor, Couper, David, Smith, Lewis J., Psaty, Bruce M., Lohman, Kurt, Burchard, Esteban G., Uitterlinden, André G., Garcia, Melissa, Joubert, Bonnie R., McArdle, Wendy L., Musk, A Bill, Hansel, Nadia, Heckbert, Susan R., Zgaga, Lina, van Meurs, Joyce B.J., Navarro, Pau, Rudan, Igor, Oh, Yeon-Mok, Redline, Susan, Jarvis, Deborah L., Zhao, Jing Hua, Rantanen, Taina, O'Connor, George T., Ripatti, Samuli, Scott, Rodney J., Karrasch, Stefan, Grallert, Harald, Gaddis, Nathan C., Starr, John M., Wijmenga, Cisca, Minster, Ryan L., Lederer, David J., Pekkanen, Juha, Gyllensten, Ulf, Campbell, Harry, Morris, Andrew P., Gläser, Sven, Hammond, Christopher J., Burkart, Kristin M, Beilby, John, Kritchevsky, Stephen B., Gudnason, Vilmundur, Hancock, Dana B., Williams, O Dale, Polasek, Ozren, Zemunik, Tatijana, Kolcic, Ivana, Petrini, Marcy F., Wjst, Matthias, Kim, Woo Jin, Porteous, David J., Smith, Blair H., Viljanen, Anne, Heliövaara, Markku, Attia, John R., Sayers, Ian, Hampel, Regina, Gieger, Christian, Deary, Ian J, Boezen, H. Marike, Newman, Anne, Jarvelin, Marjo-Riitta, Wilson, James F, Lind, Lars, Stricker, Bruno H., Teumer, Alexander, Spector, Timothy D., Melén, Erik, Peters, Marjolein J., Lange, Leslie A., Barr, R. Graham, Bracke, Ken R., Verhamme, Fien M., Sung, Joohon, Hiemstra, Pieter S., Cassano, Patricia A., Sood, Akshay, Hayward, Caroline, Dupuis, Josée, Hall, Ian P., Brusselle, Guy G., Tobin, Martin D. and London, Stephanie J. (2014) Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nature Genetics, 46 (7). pp. 669-677. ISSN 1546-1718 Genetics research Genome-wide association studies Population genetics Respiratory tract diseases http://dx.doi.org/10.1038/ng.3011 doi:10.1038/ng.3011 doi:10.1038/ng.3011
spellingShingle	Genetics research Genome-wide association studies Population genetics Respiratory tract diseases Loth, Daan W. Artigas, María Soler Gharib, Sina A. Wain, Louise V. Franceschini, Nora Koch, Beate Pottinger, Tess D. Smith, Albert Vernon Duan, Qing Oldmeadow, Chris Lee, Mi Kyeong Strachan, David P. James, Alan L. Huffman, Jennifer E. Vitart, Veronique Ramasamy, Adaikalavan Wareham, Nicholas J. Kaprio, Jaakko Wang, Xin-Qun Trochet, Holly Kähönen, Mika Flexeder, Claudia Albrecht, Eva Lopez, Lorna M. de Jong, Kim Thyagarajan, Bharat Alves, Alexessander Couto Enroth, Stefan Omenaas, Ernst Joshi, Peter K. Fall, Tove Viñuela, Ana Launer, Lenore J. Loehr, Laura R. Fornage, Myriam Li, Guo Wilk, Jemma B. Tang, Wenbo Manichaikul, Ani Lahousse, Lies Harris, Tamara B. North, Kari E. Rudnicka, Alicja R. Hui, Jennie Gu, Xiangjun Lumley, Thomas Wright, Alan F. Hastie, Nicholas D. Campbell, Susan Kumar, Rajesh Pin, Isabelle Scott, Robert A. Pietiläinen, Kirsi H. Surakka, Ida Liu, Yongmei Holliday, Elizabeth G. Schulz, Holger Heinrich, Joachim Davies, Gail Vonk, Judith M. Wojczynski, Mary Pouta, Anneli Johansson, Åsa Wild, Sarah H. Ingelsson, Erik Rivadeneira, Fernando Völzke, Henry Hysi, Pirro G. Eiriksdottir, Gudny Morrison, Alanna C. Rotter, Jerome I. Gao, Wei Postma, Dirkje S. White, Wendy B. Rich, Stephen S. Hofman, Albert Aspelund, Thor Couper, David Smith, Lewis J. Psaty, Bruce M. Lohman, Kurt Burchard, Esteban G. Uitterlinden, André G. Garcia, Melissa Joubert, Bonnie R. McArdle, Wendy L. Musk, A Bill Hansel, Nadia Heckbert, Susan R. Zgaga, Lina van Meurs, Joyce B.J. Navarro, Pau Rudan, Igor Oh, Yeon-Mok Redline, Susan Jarvis, Deborah L. Zhao, Jing Hua Rantanen, Taina O'Connor, George T. Ripatti, Samuli Scott, Rodney J. Karrasch, Stefan Grallert, Harald Gaddis, Nathan C. Starr, John M. Wijmenga, Cisca Minster, Ryan L. Lederer, David J. Pekkanen, Juha Gyllensten, Ulf Campbell, Harry Morris, Andrew P. Gläser, Sven Hammond, Christopher J. Burkart, Kristin M Beilby, John Kritchevsky, Stephen B. Gudnason, Vilmundur Hancock, Dana B. Williams, O Dale Polasek, Ozren Zemunik, Tatijana Kolcic, Ivana Petrini, Marcy F. Wjst, Matthias Kim, Woo Jin Porteous, David J. Smith, Blair H. Viljanen, Anne Heliövaara, Markku Attia, John R. Sayers, Ian Hampel, Regina Gieger, Christian Deary, Ian J Boezen, H. Marike Newman, Anne Jarvelin, Marjo-Riitta Wilson, James F Lind, Lars Stricker, Bruno H. Teumer, Alexander Spector, Timothy D. Melén, Erik Peters, Marjolein J. Lange, Leslie A. Barr, R. Graham Bracke, Ken R. Verhamme, Fien M. Sung, Joohon Hiemstra, Pieter S. Cassano, Patricia A. Sood, Akshay Hayward, Caroline Dupuis, Josée Hall, Ian P. Brusselle, Guy G. Tobin, Martin D. London, Stephanie J. Genome-wide association analysis identifies six new loci associated with forced vital capacity
title	Genome-wide association analysis identifies six new loci associated with forced vital capacity
title_full	Genome-wide association analysis identifies six new loci associated with forced vital capacity
title_fullStr	Genome-wide association analysis identifies six new loci associated with forced vital capacity
title_full_unstemmed	Genome-wide association analysis identifies six new loci associated with forced vital capacity
title_short	Genome-wide association analysis identifies six new loci associated with forced vital capacity
title_sort	genome-wide association analysis identifies six new loci associated with forced vital capacity
topic	Genetics research Genome-wide association studies Population genetics Respiratory tract diseases
url	https://eprints.nottingham.ac.uk/32637/ https://eprints.nottingham.ac.uk/32637/ https://eprints.nottingham.ac.uk/32637/

Genome-wide association analysis identifies six new loci associated with forced vital capacity

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