Abnormal visuomotor processing in schizophrenia
Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorim...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier
2015
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/32487/ |
| _version_ | 1848794419822592000 |
|---|---|
| author | Robson, Siân E. Brookes, Matthew J. Hall, Emma L. Palaniyappan, Lena Kumar, Jyothika Skelton, Michael Christodoulou, Nikolaos G. Qureshi, Ayaz Jan, Fiesal Katshu, Mohammad Z. Liddle, Elizabeth B. Liddle, Peter F. Morris, Peter G. |
| author_facet | Robson, Siân E. Brookes, Matthew J. Hall, Emma L. Palaniyappan, Lena Kumar, Jyothika Skelton, Michael Christodoulou, Nikolaos G. Qureshi, Ayaz Jan, Fiesal Katshu, Mohammad Z. Liddle, Elizabeth B. Liddle, Peter F. Morris, Peter G. |
| author_sort | Robson, Siân E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post movement beta rebound (PMBR)); while in visual cortex, gamma oscillations are increased throughout stimulus presentation. In this study, we used a selfpaced visuomotor paradigm and magnetoencephalography (MEG) to contrast these responses in patients with schizophrenia and control volunteers. We found significant reductions in the peak-to-peak change in amplitude from ERBD to PMBR in schizophrenia compared with controls. This effect was strongest in patients who made fewer movements, whereas beta was not modulated by movement in controls. There was no significant difference in the amplitude of visual gamma between patients and controls. These data demonstrate that clear abnormalities in basic sensorimotor processing in schizophrenia can be observed using a very simple MEG paradigm |
| first_indexed | 2025-11-14T19:15:54Z |
| format | Article |
| id | nottingham-32487 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:15:54Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-324872020-05-04T17:16:27Z https://eprints.nottingham.ac.uk/32487/ Abnormal visuomotor processing in schizophrenia Robson, Siân E. Brookes, Matthew J. Hall, Emma L. Palaniyappan, Lena Kumar, Jyothika Skelton, Michael Christodoulou, Nikolaos G. Qureshi, Ayaz Jan, Fiesal Katshu, Mohammad Z. Liddle, Elizabeth B. Liddle, Peter F. Morris, Peter G. Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post movement beta rebound (PMBR)); while in visual cortex, gamma oscillations are increased throughout stimulus presentation. In this study, we used a selfpaced visuomotor paradigm and magnetoencephalography (MEG) to contrast these responses in patients with schizophrenia and control volunteers. We found significant reductions in the peak-to-peak change in amplitude from ERBD to PMBR in schizophrenia compared with controls. This effect was strongest in patients who made fewer movements, whereas beta was not modulated by movement in controls. There was no significant difference in the amplitude of visual gamma between patients and controls. These data demonstrate that clear abnormalities in basic sensorimotor processing in schizophrenia can be observed using a very simple MEG paradigm Elsevier 2015-09-25 Article PeerReviewed Robson, Siân E., Brookes, Matthew J., Hall, Emma L., Palaniyappan, Lena, Kumar, Jyothika, Skelton, Michael, Christodoulou, Nikolaos G., Qureshi, Ayaz, Jan, Fiesal, Katshu, Mohammad Z., Liddle, Elizabeth B., Liddle, Peter F. and Morris, Peter G. (2015) Abnormal visuomotor processing in schizophrenia. NeuroImage: Clinical . ISSN 2213-1582 Schizophrenia magnetoencephalography motor cortex visual cortex electrophysiological processes http://www.sciencedirect.com/science/article/pii/S2213158215001436 doi:10.1016/j.nicl.2015.08.005 doi:10.1016/j.nicl.2015.08.005 |
| spellingShingle | Schizophrenia magnetoencephalography motor cortex visual cortex electrophysiological processes Robson, Siân E. Brookes, Matthew J. Hall, Emma L. Palaniyappan, Lena Kumar, Jyothika Skelton, Michael Christodoulou, Nikolaos G. Qureshi, Ayaz Jan, Fiesal Katshu, Mohammad Z. Liddle, Elizabeth B. Liddle, Peter F. Morris, Peter G. Abnormal visuomotor processing in schizophrenia |
| title | Abnormal visuomotor processing in schizophrenia |
| title_full | Abnormal visuomotor processing in schizophrenia |
| title_fullStr | Abnormal visuomotor processing in schizophrenia |
| title_full_unstemmed | Abnormal visuomotor processing in schizophrenia |
| title_short | Abnormal visuomotor processing in schizophrenia |
| title_sort | abnormal visuomotor processing in schizophrenia |
| topic | Schizophrenia magnetoencephalography motor cortex visual cortex electrophysiological processes |
| url | https://eprints.nottingham.ac.uk/32487/ https://eprints.nottingham.ac.uk/32487/ https://eprints.nottingham.ac.uk/32487/ |