Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD

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Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD

Growing evidence implicates impairment of autophagy as a candidate pathogenic mechanism in the spectrum of neurodegenerative disorders which includes amyotrophic lateral sclerosis and frontotemporal lobar degeneration (ALS-FTLD). SQSTM1, which encodes the autophagy receptor SQSTM1/p62, is geneticall...

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Bibliographic Details
Main Authors:	Goode, Alice, Butler, Kevin, Long, Jed, Cavey, James, Scott, Daniel, Shaw, Barry, Sollenberger, Jill, Gell, Christopher, Johansen, Terje, Oldham, Neil J., Searle, Mark S., Layfield, Robert
Format:	Article
Published:	Taylor & Francis 2016
Subjects:	ALS Atg8/LC3 autophagy FTLD LIR SQSTM1/p62
Online Access:	https://eprints.nottingham.ac.uk/32410/

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