A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model

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A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold for bone repair and delivers antibiotics at high co...

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Bibliographic Details
Main Authors:	McLaren, Jane S., White, L.J., Cox, H.C., Ashraf, Waheed, Rahman, C.V., Blunn, G.W., Goodship, A.E., Quirk, R.A., Shakesheff, Kevin M., Bayston, Roger, Scammell, Brigitte E.
Format:	Article
Published:	AO Foundation 2014
Subjects:	PLGA; biodegradable scaffold; infection; in vivo; bone ingrowth
Online Access:	https://eprints.nottingham.ac.uk/32295/

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