Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlappi...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier
2016
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/32269/ |
| _version_ | 1848794373915934720 |
|---|---|
| author | Guerreiro, Rita Escott-Price, Valentina Darwent, Lee Parkkinen, Laura Ansorge, Olaf Hernandez, Dena Nalls, Michael A. Clark, Lorraine Honig, Lawrence Marder, Karen Flier, Wiesje van der Holstege, Henne Louwersheimer, Eva Lemstra, Afina Scheltens, Philip Barber, Imelda S. Braae, Anne Brown, Kristelle Morgan, Kevin |
| author_facet | Guerreiro, Rita Escott-Price, Valentina Darwent, Lee Parkkinen, Laura Ansorge, Olaf Hernandez, Dena Nalls, Michael A. Clark, Lorraine Honig, Lawrence Marder, Karen Flier, Wiesje van der Holstege, Henne Louwersheimer, Eva Lemstra, Afina Scheltens, Philip Barber, Imelda S. Braae, Anne Brown, Kristelle Morgan, Kevin |
| author_sort | Guerreiro, Rita |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. |
| first_indexed | 2025-11-14T19:15:10Z |
| format | Article |
| id | nottingham-32269 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:15:10Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-322692020-05-04T20:04:03Z https://eprints.nottingham.ac.uk/32269/ Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases Guerreiro, Rita Escott-Price, Valentina Darwent, Lee Parkkinen, Laura Ansorge, Olaf Hernandez, Dena Nalls, Michael A. Clark, Lorraine Honig, Lawrence Marder, Karen Flier, Wiesje van der Holstege, Henne Louwersheimer, Eva Lemstra, Afina Scheltens, Philip Barber, Imelda S. Braae, Anne Brown, Kristelle Morgan, Kevin The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. Elsevier 2016-02 Article PeerReviewed Guerreiro, Rita, Escott-Price, Valentina, Darwent, Lee, Parkkinen, Laura, Ansorge, Olaf, Hernandez, Dena, Nalls, Michael A., Clark, Lorraine, Honig, Lawrence, Marder, Karen, Flier, Wiesje van der, Holstege, Henne, Louwersheimer, Eva, Lemstra, Afina, Scheltens, Philip, Barber, Imelda S., Braae, Anne, Brown, Kristelle and Morgan, Kevin (2016) Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases. Neurobiology of Aging, 38 . p. 214. ISSN 1558-1497 Dementia with Lewy bodies; Alzheimer's disease; Parkinson's disease; Genetic correlation http://www.sciencedirect.com/science/article/pii/S0197458015005400 doi:10.1016/j.neurobiolaging.2015.10.028 doi:10.1016/j.neurobiolaging.2015.10.028 |
| spellingShingle | Dementia with Lewy bodies; Alzheimer's disease; Parkinson's disease; Genetic correlation Guerreiro, Rita Escott-Price, Valentina Darwent, Lee Parkkinen, Laura Ansorge, Olaf Hernandez, Dena Nalls, Michael A. Clark, Lorraine Honig, Lawrence Marder, Karen Flier, Wiesje van der Holstege, Henne Louwersheimer, Eva Lemstra, Afina Scheltens, Philip Barber, Imelda S. Braae, Anne Brown, Kristelle Morgan, Kevin Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases |
| title | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases |
| title_full | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases |
| title_fullStr | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases |
| title_full_unstemmed | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases |
| title_short | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases |
| title_sort | genome-wide analysis of genetic correlation in dementia with lewy bodies, alzheimer’s and parkinson’s diseases |
| topic | Dementia with Lewy bodies; Alzheimer's disease; Parkinson's disease; Genetic correlation |
| url | https://eprints.nottingham.ac.uk/32269/ https://eprints.nottingham.ac.uk/32269/ https://eprints.nottingham.ac.uk/32269/ |