Common polygenic variation can predict risk of Alzheimer’s disease

Common polygenic variation can predict risk of Alzheimer’s disease

Background: The identification of subjects at high risk for Alzheimer’s disease is important for prognosis and early intervention. We investigated the polygenic architecture of Alzheimer’s disease (AD) and the accuracy of AD prediction models, including and excluding the polygenic component in the m...

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Main Authors: Escott-Price, Valentina, Sims, Rebecca, Bannister, Christian, Harold, Denise, Vronskaya, Maria, Majounie, Elisa, Badarinarayan, Nandini, Morgan, Kevin, Passmore, Peter, Holmes, Clive, Powell, John, Lovestone, Simon, Brayne, Carol, Gill, Michael, Mead, Simon, Goate, Alison, Cruchaga, Carlos, Lambert, Jean-Charles, van Duijn, Cornelia, Maier, Wolfgang, Ramirez, Alfredo, Holmans, Peter, Jones, Lesley, Hardy, John, Seshadri, Sudha, Schellenberg, Gerard D., Amouyel, Philippe, Williams, Julie
Format: Article
Published: Oxford Univerity Press 2015
Subjects:
Alzheimer’s disease
polygenic score
predictive model
Online Access:https://eprints.nottingham.ac.uk/32217/

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