Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility

Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility

Background Alzheimer’s disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyperphosphorylated tau and cell death. Since proteins in the SNAP (Soluble N-et...

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Main Authors: Sevlever, Daniel, Zou, Fanggeng, Ma, Li, Carrasquillo, Sebastian, Crump, Michael G., Culley, Oliver J., Hunter, Talisha A., Bisceglio, Gina D., Younkin, Linda, Allen, Mariet, Carrasquillo, Minerva M., Sando, Sigrid B., Aasly, Jan O., Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., Morgan, Kevin, Belbin, Olivia
Format: Article
Published: Springer 2015
Subjects:
SNARE
Vesicle-Associated Membrane Protein 1
β-amyloid
Alzheimer’s disease
Synapse
Online Access:https://eprints.nottingham.ac.uk/32210/

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