Combinatorial discovery of polymers resistant to bacterial attachment
Bacterial attachment and subsequent biofilm formation are key challenges to the long term performance of many medical devices. Here, a high throughput approach coupled with the analysis of surface structure-property relationships using a chemometics approach has been developed to simultaneously inve...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Nature Publishing Group
2012
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| Online Access: | https://eprints.nottingham.ac.uk/32096/ |
| _version_ | 1848794334737989632 |
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| author | Hook, Andrew L. Chang, Chien-Yi Yang, Jing Luckett, Jeni Cockayne, Alan Atkinson, Steve Mei, Ying Bayston, Roger Irvine, Derek J. Langer, Robert Anderson, Daniel G. Williams, Paul Davies, Martyn C. Alexander, Morgan R. |
| author_facet | Hook, Andrew L. Chang, Chien-Yi Yang, Jing Luckett, Jeni Cockayne, Alan Atkinson, Steve Mei, Ying Bayston, Roger Irvine, Derek J. Langer, Robert Anderson, Daniel G. Williams, Paul Davies, Martyn C. Alexander, Morgan R. |
| author_sort | Hook, Andrew L. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Bacterial attachment and subsequent biofilm formation are key challenges to the long term performance of many medical devices. Here, a high throughput approach coupled with the analysis of surface structure-property relationships using a chemometics approach has been developed to simultaneously investigate the interaction of bacteria with hundreds of polymeric materials on a microarray format. Using this system, a new group of materials comprising ester and hydrophobic moieties are identified that dramatically reduce the attachment of clinically relevant, pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus and uropathogenic Escherichia coli). Hit materials coated on silicone catheters resulted in up to a 30 fold reduction in coverage compared to a commercial silver embedded catheter, which has been proven to half the incidence of clinically acquired infection. These polymers represent a new class of materials resistant to bacterial attachment that could not have been predicted from the current understanding of bacteria-surface interactions. |
| first_indexed | 2025-11-14T19:14:33Z |
| format | Article |
| id | nottingham-32096 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:14:33Z |
| publishDate | 2012 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-320962020-05-04T16:33:49Z https://eprints.nottingham.ac.uk/32096/ Combinatorial discovery of polymers resistant to bacterial attachment Hook, Andrew L. Chang, Chien-Yi Yang, Jing Luckett, Jeni Cockayne, Alan Atkinson, Steve Mei, Ying Bayston, Roger Irvine, Derek J. Langer, Robert Anderson, Daniel G. Williams, Paul Davies, Martyn C. Alexander, Morgan R. Bacterial attachment and subsequent biofilm formation are key challenges to the long term performance of many medical devices. Here, a high throughput approach coupled with the analysis of surface structure-property relationships using a chemometics approach has been developed to simultaneously investigate the interaction of bacteria with hundreds of polymeric materials on a microarray format. Using this system, a new group of materials comprising ester and hydrophobic moieties are identified that dramatically reduce the attachment of clinically relevant, pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus and uropathogenic Escherichia coli). Hit materials coated on silicone catheters resulted in up to a 30 fold reduction in coverage compared to a commercial silver embedded catheter, which has been proven to half the incidence of clinically acquired infection. These polymers represent a new class of materials resistant to bacterial attachment that could not have been predicted from the current understanding of bacteria-surface interactions. Nature Publishing Group 2012-08-12 Article PeerReviewed Hook, Andrew L., Chang, Chien-Yi, Yang, Jing, Luckett, Jeni, Cockayne, Alan, Atkinson, Steve, Mei, Ying, Bayston, Roger, Irvine, Derek J., Langer, Robert, Anderson, Daniel G., Williams, Paul, Davies, Martyn C. and Alexander, Morgan R. (2012) Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30 (9). pp. 868-875. ISSN 1546-1696 Bacterial Adhesion Biomedical Materials Polymer Synthesis http://www.nature.com/nbt/journal/v30/n9/full/nbt.2316.html doi:10.1038/nbt.2316 doi:10.1038/nbt.2316 |
| spellingShingle | Bacterial Adhesion Biomedical Materials Polymer Synthesis Hook, Andrew L. Chang, Chien-Yi Yang, Jing Luckett, Jeni Cockayne, Alan Atkinson, Steve Mei, Ying Bayston, Roger Irvine, Derek J. Langer, Robert Anderson, Daniel G. Williams, Paul Davies, Martyn C. Alexander, Morgan R. Combinatorial discovery of polymers resistant to bacterial attachment |
| title | Combinatorial discovery of polymers resistant to bacterial attachment |
| title_full | Combinatorial discovery of polymers resistant to bacterial attachment |
| title_fullStr | Combinatorial discovery of polymers resistant to bacterial attachment |
| title_full_unstemmed | Combinatorial discovery of polymers resistant to bacterial attachment |
| title_short | Combinatorial discovery of polymers resistant to bacterial attachment |
| title_sort | combinatorial discovery of polymers resistant to bacterial attachment |
| topic | Bacterial Adhesion Biomedical Materials Polymer Synthesis |
| url | https://eprints.nottingham.ac.uk/32096/ https://eprints.nottingham.ac.uk/32096/ https://eprints.nottingham.ac.uk/32096/ |