Effects of age on motor excitability measures from children and adolescents with Tourette syndrome
Tourette syndrome (TS) is a neurological disorder characterised by vocal and motor tics. It is associated with cortical–striatal–thalamic–cortical circuit [CSTC] dysfunction and hyper-excitability of cortical motor regions. TS follows a developmental time course, in which tics often become increasin...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier
2016
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/32069/ |
| _version_ | 1848794328310218752 |
|---|---|
| author | Pépés, Sophia E. Draper, Amelia Jackson, Georgina M. Jackson, Stephen R. |
| author_facet | Pépés, Sophia E. Draper, Amelia Jackson, Georgina M. Jackson, Stephen R. |
| author_sort | Pépés, Sophia E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Tourette syndrome (TS) is a neurological disorder characterised by vocal and motor tics. It is associated with cortical–striatal–thalamic–cortical circuit [CSTC] dysfunction and hyper-excitability of cortical motor regions. TS follows a developmental time course, in which tics often become increasingly more controlled during adolescence. Importantly, however, a substantial minority of patients continue to have debilitating tics into adulthood. This indicates that there may be important differences between adult TS patients and children and adolescents with the disorder. We use TMS to examine cortical motor excitability in a sample of children, adolescents and young adults with TS. We demonstrate that, in contrast to studies of adult patients, resting motor threshold and the variability of MEP responses are increased in children with TS, while the gain of motor excitability in reduced. Importantly, we demonstrate that these differences normalise with age over adolescence. We conclude that these effects are likely due to a developmental delay in the maturation of key brain networks in TS, consistent with recent brain imaging studies of structural and functional brain connectivity. Importantly, these findings suggest that the alterations in brain network structure and function associated with TS may be quite different in children and adult patients with the condition. |
| first_indexed | 2025-11-14T19:14:27Z |
| format | Article |
| id | nottingham-32069 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:14:27Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-320692020-05-04T17:48:50Z https://eprints.nottingham.ac.uk/32069/ Effects of age on motor excitability measures from children and adolescents with Tourette syndrome Pépés, Sophia E. Draper, Amelia Jackson, Georgina M. Jackson, Stephen R. Tourette syndrome (TS) is a neurological disorder characterised by vocal and motor tics. It is associated with cortical–striatal–thalamic–cortical circuit [CSTC] dysfunction and hyper-excitability of cortical motor regions. TS follows a developmental time course, in which tics often become increasingly more controlled during adolescence. Importantly, however, a substantial minority of patients continue to have debilitating tics into adulthood. This indicates that there may be important differences between adult TS patients and children and adolescents with the disorder. We use TMS to examine cortical motor excitability in a sample of children, adolescents and young adults with TS. We demonstrate that, in contrast to studies of adult patients, resting motor threshold and the variability of MEP responses are increased in children with TS, while the gain of motor excitability in reduced. Importantly, we demonstrate that these differences normalise with age over adolescence. We conclude that these effects are likely due to a developmental delay in the maturation of key brain networks in TS, consistent with recent brain imaging studies of structural and functional brain connectivity. Importantly, these findings suggest that the alterations in brain network structure and function associated with TS may be quite different in children and adult patients with the condition. Elsevier 2016-06-01 Article PeerReviewed Pépés, Sophia E., Draper, Amelia, Jackson, Georgina M. and Jackson, Stephen R. (2016) Effects of age on motor excitability measures from children and adolescents with Tourette syndrome. Developmental Cognitive Neuroscience, 19 . pp. 78-86. ISSN 1878-9307 Tourette syndrome; Motor excitability; Transcranial magnetic stimulation (TMS); Motor threshold; Children and adolescents http://www.sciencedirect.com/science/article/pii/S1878929315300578 doi:10.1016/j.dcn.2016.02.005 doi:10.1016/j.dcn.2016.02.005 |
| spellingShingle | Tourette syndrome; Motor excitability; Transcranial magnetic stimulation (TMS); Motor threshold; Children and adolescents Pépés, Sophia E. Draper, Amelia Jackson, Georgina M. Jackson, Stephen R. Effects of age on motor excitability measures from children and adolescents with Tourette syndrome |
| title | Effects of age on motor excitability measures from children and adolescents with Tourette syndrome |
| title_full | Effects of age on motor excitability measures from children and adolescents with Tourette syndrome |
| title_fullStr | Effects of age on motor excitability measures from children and adolescents with Tourette syndrome |
| title_full_unstemmed | Effects of age on motor excitability measures from children and adolescents with Tourette syndrome |
| title_short | Effects of age on motor excitability measures from children and adolescents with Tourette syndrome |
| title_sort | effects of age on motor excitability measures from children and adolescents with tourette syndrome |
| topic | Tourette syndrome; Motor excitability; Transcranial magnetic stimulation (TMS); Motor threshold; Children and adolescents |
| url | https://eprints.nottingham.ac.uk/32069/ https://eprints.nottingham.ac.uk/32069/ https://eprints.nottingham.ac.uk/32069/ |