Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place
There is increasing focus on the role of the nucleus accumbens (NAc) in learning and memory, but there is little consensus as to how the core and medial shell subregions of the NAc contribute to these processes. In the current experiments, we used spontaneous object recognition to test rats with 6-h...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
American Psychological Association
2010
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/3204/ |
| _version_ | 1848790976794984448 |
|---|---|
| author | Nelson, Andrew J.D. Thur, Karen E. Marsden, Charles A. Cassaday, Helen J. |
| author_facet | Nelson, Andrew J.D. Thur, Karen E. Marsden, Charles A. Cassaday, Helen J. |
| author_sort | Nelson, Andrew J.D. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | There is increasing focus on the role of the nucleus accumbens (NAc) in learning and memory, but there is little consensus as to how the core and medial shell subregions of the NAc contribute to these processes. In the current experiments, we used spontaneous object recognition to test rats with 6-hydroxydopamine lesions targeted at the core or medial shell of the NAc on a familiarity discrimination task and a location discrimination task. In the object recognition variant, control animals were able to discriminate the novel object at both 24-hr and 5-min delay. However, in the lesion groups, performance was systematically related to dopamine (DA) levels in the core but not the shell. In the location recognition task, sham-operated animals readily detected the object displacement at test. In the lesion groups, performance impairment was systematically related to DA levels in the shell but not the core. These results suggest that dopamine function within distinct subregions of the NAc plays dissociable roles in the modulation of memory for objects and place. |
| first_indexed | 2025-11-14T18:21:10Z |
| format | Article |
| id | nottingham-3204 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:21:10Z |
| publishDate | 2010 |
| publisher | American Psychological Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-32042020-05-04T20:24:43Z https://eprints.nottingham.ac.uk/3204/ Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place Nelson, Andrew J.D. Thur, Karen E. Marsden, Charles A. Cassaday, Helen J. There is increasing focus on the role of the nucleus accumbens (NAc) in learning and memory, but there is little consensus as to how the core and medial shell subregions of the NAc contribute to these processes. In the current experiments, we used spontaneous object recognition to test rats with 6-hydroxydopamine lesions targeted at the core or medial shell of the NAc on a familiarity discrimination task and a location discrimination task. In the object recognition variant, control animals were able to discriminate the novel object at both 24-hr and 5-min delay. However, in the lesion groups, performance was systematically related to dopamine (DA) levels in the core but not the shell. In the location recognition task, sham-operated animals readily detected the object displacement at test. In the lesion groups, performance impairment was systematically related to DA levels in the shell but not the core. These results suggest that dopamine function within distinct subregions of the NAc plays dissociable roles in the modulation of memory for objects and place. American Psychological Association 2010-12 Article PeerReviewed Nelson, Andrew J.D., Thur, Karen E., Marsden, Charles A. and Cassaday, Helen J. (2010) Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place. Behavioral Neuroscience, 124 (6). pp. 789-799. ISSN 0735-7044 nucleus accumbens; dopamine; rat; object memory; place memory http://psycnet.apa.org/journals/bne/124/6/789.html doi:10.1037/a0021114 doi:10.1037/a0021114 |
| spellingShingle | nucleus accumbens; dopamine; rat; object memory; place memory Nelson, Andrew J.D. Thur, Karen E. Marsden, Charles A. Cassaday, Helen J. Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place |
| title | Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place |
| title_full | Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place |
| title_fullStr | Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place |
| title_full_unstemmed | Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place |
| title_short | Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place |
| title_sort | dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place |
| topic | nucleus accumbens; dopamine; rat; object memory; place memory |
| url | https://eprints.nottingham.ac.uk/3204/ https://eprints.nottingham.ac.uk/3204/ https://eprints.nottingham.ac.uk/3204/ |