Cuprate addition to a 6-substituted pentafulvene: preparation of sec-alkyl substituted titanocene dichlorides and their biological activity

QR Code

Cuprate addition to a 6-substituted pentafulvene: preparation of sec-alkyl substituted titanocene dichlorides and their biological activity

The copper-catalysed (10 mol-% CuBr·SMe2, CuCN·LiCl or CuI/PPh3) addition of RMgBr to the pentafulvene 1-(cyclopenta-2,4-dien-1-ylidenemethyl)-2-methoxybenzene allows the formation of cyclopentadienyl derivatives with α-CHR(2-MeOPh) sidechains (R = Me, Et, nBu, iBu, allyl, Ph) without H– transfer. T...

Full description

Bibliographic Details
Main Authors:	Cini, Melchior, Bradshaw, Tracey D., Lewis, William, Woodward, Simon
Format:	Article
Published:	Wiley-VCH Verlag 2013
Online Access:	https://eprints.nottingham.ac.uk/3200/

Similar Items

Asymmetric pentafulvene carbometalation-access to enantiopure titanocene dichlorides of biological relevance
by: Cini, Melchior, et al.
Published: (2015)

Synthesis and biological evaluation of enantiopure substituted titanocene complexes
by: Cini, Melchior
Published: (2015)

Enantiopure titanocene complexes: direct evidence for paraptosis in cancer cells
by: Cini, Melchior, et al.
Published: (2016)

Enantiopure titanocene complexes: direct evidence for paraptosis in cancer cells
by: Cini, Melchior, et al.
Published: (2016)

Enantioselective synthesis of 6,6-disubstituted pentafulvenes containing a chiral pendant hydroxy group
by: Nouch, Ryan, et al.
Published: (2017)

Superconductivity in Layerd Cuprate
by: Abd Shukor, Roslan, et al.
Published: (2005)

An efficient synthesis of substituted chrysenes
by: Eccleshare, Lee, et al.
Published: (2017)

Synthesis of highly substituted 1,2-diazetidin-3-ones, small ring scaffolds for drug discovery
by: Santos, Marilla S., et al.
Published: (2018)

Organocatalytic synthesis of Pentafulvene derivatives and kinetic analysis of copper catalyzed 1,4-addition
by: Nouch, Ryan
Published: (2020)

Using titanium complexes to defeat cancer: the view from the shoulders of titans
by: Cini, Melchoir, et al.
Published: (2017)

Barium zirconate ceramics for melt processing of barium cuprate superconductors
by: Kirby, Nigel Matthew
Published: (2003)

Straightforward synthesis of 2- and 2,8-substituted tetracenes
by: Woodward, Simon, et al.
Published: (2017)

Paraquat dichloride detection from forensic blowfly samples
by: Wan Mohd Asyraf Wan Mahmood,, et al.
Published: (2015)

Identification of alkyl substituted 2H-furo[2,3-c]pyran-2-ones as germination stimulants present in smoke
by: Flematti, G., et al.
Published: (2009)

Exploring the reactivity of 2-trichloromethylbenzoxazoles for access to substituted benzoxazoles
by: Lester, Roy P., et al.
Published: (2016)

Effect of Processing Conditions, Additives and Starch Substitution on the Quality of Starch Noodle
by: Kusnandar, Feri
Published: (1998)

Electronic and photoelectron spectroscopy of substituted benzene molecules
by: Tuttle, William Duncan
Published: (2018)

Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction
by: Nicolle, Simon M., et al.
Published: (2015)

Synthesis and thermoelectric properties of 2- and 2,8-substituted tetrathiotetracenes
by: Robert Garrett, Mary, et al.
Published: (2018)

Influence of cobalt substitution on the structural and magnetic properties of cobalt substituted magnetite
by: Soleimani, Hassan, et al.
Published: (2016)

Polyalphabetic substitution cipher
by: Alshaikhli, Imad Fakhri Taha, et al.
Published: (2011)

Monoalphabetic substitution cipher
by: Alshaikhli, Imad Fakhri Taha, et al.
Published: (2011)

Antihyprtensive Activity Of Para-substituted Clonidine Analogues And Their Acylated Derivatives
by: Lewis, Alan Martin
Published: (1994)

Characterization And Effect Of Sn(Iv) Chlorin E6 Dichloride Trisodium Salt In Photodynamic Therapy
by: Al-Khaza'leh, Khaled Abdu Bdaiwi
Published: (2009)

A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines
by: Lim, Felicia Phei Lin, et al.
Published: (2018)

A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-: A] [1,3,5]triazines
by: Lim, F., et al.
Published: (2018)

Spectroscopy of substituted benzene molecules
by: Andrejeva, Anna
Published: (2016)

Titanium substitution mechanisms in forsterite
by: Berry, A., et al.
Published: (2007)

Synthesis Of 2-substituted N-heterocycles via asymmetric organocatalysed intramolecular N-conjugate addition
by: Grant, Kevan Michael
Published: (2017)

Enhancing absorption properties of Mg–Ti substituted barium hexaferrite nanocomposite through the addition of MWCNT
by: Mustaffa, Muhammad Syazwan, et al.
Published: (2017)

Core-substituted naphthalene diimides: influence of substituent conformation on strong visible absorption
by: Quinn, Samuel, et al.
Published: (2017)

Synthetic approaches to 2-substituted pyrazines and 2-substituted quinoxalines and their fluorescence characteristics / Azila Mohd Idris
by: Mohd Idris, Azila
Published: (2009)

Substituted naphthoquinones as novel amino acid sensitive reagents for the detection of latent fingermarks on paper surfaces
by: Jelly, R., et al.
Published: (2010)

Simplified E-Content system (SECS)
by: Oon, Seau Foong
Published: (2014)

Synthesis and characterisation of multi-substituted hydroxyapatites
by: McCarthy, Benjamin P.
Published: (2018)

Substitution of Manual Production Labor by Automation
by: Lee, Lai Samm
Published: (2017)

Fluid substitution in heavy oil rocks
by: Makarynska, D., et al.
Published: (2018)

Packet loss and frame substitution techniques
by: Shah, Asadullah, et al.
Published: (2011)

Role of ceramics as bone graft substitutes
by: Vikram, David, et al.
Published: (2005)

Fluid substitution in heavy oil rocks
by: Makarynska, Dina, et al.
Published: (2008)