Toward mid-infrared, subdiffraction, spectral-mapping of human cells and tissue: SNIM (scanning near-field infrared microscopy) tip fabrication
Scanning near-field infrared microscopy (SNIM) potentially enables subdiffraction, broadband mid-infrared (MIR:3–25-μm wavelength range) spectral-mapping of human cells and tissue for real-time molecular sensing, with prospective use in disease diagnosis. SNIM requires an MIR-transmitting tip of sma...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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Institute of Electrical and Electronics Engineers
2016
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| Online Access: | https://eprints.nottingham.ac.uk/31997/ |
| _version_ | 1848794313763323904 |
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| author | Athanasiou, Giorgos S. Ernst, Johanna Furniss, David Benson, Trevor M. Chauhan, Jasbinder Middleton, John Parmenter, Christopher D.J. Fay, Mike W. Neate, Nigel C. Shiryaev, Vladimir Churbanov, Mikhail F. Seddon, Angela B. |
| author_facet | Athanasiou, Giorgos S. Ernst, Johanna Furniss, David Benson, Trevor M. Chauhan, Jasbinder Middleton, John Parmenter, Christopher D.J. Fay, Mike W. Neate, Nigel C. Shiryaev, Vladimir Churbanov, Mikhail F. Seddon, Angela B. |
| author_sort | Athanasiou, Giorgos S. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Scanning near-field infrared microscopy (SNIM) potentially enables subdiffraction, broadband mid-infrared (MIR:3–25-μm wavelength range) spectral-mapping of human cells and tissue for real-time molecular sensing, with prospective use in disease diagnosis. SNIM requires an MIR-transmitting tip of small aperture for photon collection. Here, chalcogenide-glass optical fibers are reproducibly tapered at one end to form a MIR transmitting tip for SNIM. A wet-etching method is used to form the tip. The tapering sides of the tip are Al-coated. These Al-coated tapered-tips exhibit near-field power-confinement when acting either as the launch-end or exit-end of the MIR optical fiber. We report first time optimal cleaving of the end of the tapered tip using focused ion beam milling. A flat aperture is produced at the end of the tip, which is orthogonal to the fiber-axis and of controlled diameter. A FIB-cleaved aperture is used to collect MIR spectra of cells mounted on a transflection plate, under illumination of a synchrotron- generated wideband MIR beam. |
| first_indexed | 2025-11-14T19:14:13Z |
| format | Article |
| id | nottingham-31997 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:14:13Z |
| publishDate | 2016 |
| publisher | Institute of Electrical and Electronics Engineers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-319972020-05-04T17:36:58Z https://eprints.nottingham.ac.uk/31997/ Toward mid-infrared, subdiffraction, spectral-mapping of human cells and tissue: SNIM (scanning near-field infrared microscopy) tip fabrication Athanasiou, Giorgos S. Ernst, Johanna Furniss, David Benson, Trevor M. Chauhan, Jasbinder Middleton, John Parmenter, Christopher D.J. Fay, Mike W. Neate, Nigel C. Shiryaev, Vladimir Churbanov, Mikhail F. Seddon, Angela B. Scanning near-field infrared microscopy (SNIM) potentially enables subdiffraction, broadband mid-infrared (MIR:3–25-μm wavelength range) spectral-mapping of human cells and tissue for real-time molecular sensing, with prospective use in disease diagnosis. SNIM requires an MIR-transmitting tip of small aperture for photon collection. Here, chalcogenide-glass optical fibers are reproducibly tapered at one end to form a MIR transmitting tip for SNIM. A wet-etching method is used to form the tip. The tapering sides of the tip are Al-coated. These Al-coated tapered-tips exhibit near-field power-confinement when acting either as the launch-end or exit-end of the MIR optical fiber. We report first time optimal cleaving of the end of the tapered tip using focused ion beam milling. A flat aperture is produced at the end of the tip, which is orthogonal to the fiber-axis and of controlled diameter. A FIB-cleaved aperture is used to collect MIR spectra of cells mounted on a transflection plate, under illumination of a synchrotron- generated wideband MIR beam. Institute of Electrical and Electronics Engineers 2016-02-15 Article PeerReviewed Athanasiou, Giorgos S., Ernst, Johanna, Furniss, David, Benson, Trevor M., Chauhan, Jasbinder, Middleton, John, Parmenter, Christopher D.J., Fay, Mike W., Neate, Nigel C., Shiryaev, Vladimir, Churbanov, Mikhail F. and Seddon, Angela B. (2016) Toward mid-infrared, subdiffraction, spectral-mapping of human cells and tissue: SNIM (scanning near-field infrared microscopy) tip fabrication. Journal of Lightwave Technology, 34 (4). 1212 -1219. ISSN 1558-2213 Chalcogenide Glass Chemical Etching Fiber Processing Mid-Infrared Transflection Spectra http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7317727 doi:10.1109/JLT.2015.2496786 doi:10.1109/JLT.2015.2496786 |
| spellingShingle | Chalcogenide Glass Chemical Etching Fiber Processing Mid-Infrared Transflection Spectra Athanasiou, Giorgos S. Ernst, Johanna Furniss, David Benson, Trevor M. Chauhan, Jasbinder Middleton, John Parmenter, Christopher D.J. Fay, Mike W. Neate, Nigel C. Shiryaev, Vladimir Churbanov, Mikhail F. Seddon, Angela B. Toward mid-infrared, subdiffraction, spectral-mapping of human cells and tissue: SNIM (scanning near-field infrared microscopy) tip fabrication |
| title | Toward mid-infrared, subdiffraction, spectral-mapping of human cells and tissue: SNIM (scanning near-field infrared microscopy) tip fabrication |
| title_full | Toward mid-infrared, subdiffraction, spectral-mapping of human cells and tissue: SNIM (scanning near-field infrared microscopy) tip fabrication |
| title_fullStr | Toward mid-infrared, subdiffraction, spectral-mapping of human cells and tissue: SNIM (scanning near-field infrared microscopy) tip fabrication |
| title_full_unstemmed | Toward mid-infrared, subdiffraction, spectral-mapping of human cells and tissue: SNIM (scanning near-field infrared microscopy) tip fabrication |
| title_short | Toward mid-infrared, subdiffraction, spectral-mapping of human cells and tissue: SNIM (scanning near-field infrared microscopy) tip fabrication |
| title_sort | toward mid-infrared, subdiffraction, spectral-mapping of human cells and tissue: snim (scanning near-field infrared microscopy) tip fabrication |
| topic | Chalcogenide Glass Chemical Etching Fiber Processing Mid-Infrared Transflection Spectra |
| url | https://eprints.nottingham.ac.uk/31997/ https://eprints.nottingham.ac.uk/31997/ https://eprints.nottingham.ac.uk/31997/ |