High throughput screening for discovery of materials that control stem cell fate
Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem ce...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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Elsevier
2016
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| Online Access: | https://eprints.nottingham.ac.uk/31927/ |
| _version_ | 1848794298116472832 |
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| author | Patel, Asha K. Tibbitt, Mark Celiz, Adam D. Davies, Martyn C. Langer, Robert Denning, Chris Alexander, Morgan R. Anderson, Daniel G. |
| author_facet | Patel, Asha K. Tibbitt, Mark Celiz, Adam D. Davies, Martyn C. Langer, Robert Denning, Chris Alexander, Morgan R. Anderson, Daniel G. |
| author_sort | Patel, Asha K. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior. |
| first_indexed | 2025-11-14T19:13:58Z |
| format | Article |
| id | nottingham-31927 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:13:58Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-319272020-05-04T17:36:09Z https://eprints.nottingham.ac.uk/31927/ High throughput screening for discovery of materials that control stem cell fate Patel, Asha K. Tibbitt, Mark Celiz, Adam D. Davies, Martyn C. Langer, Robert Denning, Chris Alexander, Morgan R. Anderson, Daniel G. Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior. Elsevier 2016-02-22 Article PeerReviewed Patel, Asha K., Tibbitt, Mark, Celiz, Adam D., Davies, Martyn C., Langer, Robert, Denning, Chris, Alexander, Morgan R. and Anderson, Daniel G. (2016) High throughput screening for discovery of materials that control stem cell fate. Current Opinion in Solid State and Materials Science . ISSN 1879-0348 (In Press) Stem cells; Differentiation; Biomaterials; High throughput screening; 3D http://www.sciencedirect.com/science/article/pii/S1359028616300055 doi:10.1016/j.cossms.2016.02.002 doi:10.1016/j.cossms.2016.02.002 |
| spellingShingle | Stem cells; Differentiation; Biomaterials; High throughput screening; 3D Patel, Asha K. Tibbitt, Mark Celiz, Adam D. Davies, Martyn C. Langer, Robert Denning, Chris Alexander, Morgan R. Anderson, Daniel G. High throughput screening for discovery of materials that control stem cell fate |
| title | High throughput screening for discovery of materials that control stem cell fate |
| title_full | High throughput screening for discovery of materials that control stem cell fate |
| title_fullStr | High throughput screening for discovery of materials that control stem cell fate |
| title_full_unstemmed | High throughput screening for discovery of materials that control stem cell fate |
| title_short | High throughput screening for discovery of materials that control stem cell fate |
| title_sort | high throughput screening for discovery of materials that control stem cell fate |
| topic | Stem cells; Differentiation; Biomaterials; High throughput screening; 3D |
| url | https://eprints.nottingham.ac.uk/31927/ https://eprints.nottingham.ac.uk/31927/ https://eprints.nottingham.ac.uk/31927/ |