Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis
BACKGROUND: Fetal macrosomia is associated with an increased risk of adverse maternal and neonatal outcomes. OBJECTIVES: To compare the accuracy of antenatal two-dimensional (2D) ultrasound, three-dimensional (3D) ultrasound, and magnetic resonance imaging (MRI) in predicting fetal macros...
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| Format: | Article |
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Wiley
2016
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| Online Access: | https://eprints.nottingham.ac.uk/31857/ |
| _version_ | 1848794286415413248 |
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| author | Malin, G.L. Bugg, George Takwoingi, Yemisi Thornton, Jim Jones, Nia W. |
| author_facet | Malin, G.L. Bugg, George Takwoingi, Yemisi Thornton, Jim Jones, Nia W. |
| author_sort | Malin, G.L. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | BACKGROUND:
Fetal macrosomia is associated with an increased risk of adverse maternal and neonatal outcomes.
OBJECTIVES:
To compare the accuracy of antenatal two-dimensional (2D) ultrasound, three-dimensional (3D) ultrasound, and magnetic resonance imaging (MRI) in predicting fetal macrosomia at birth.
SEARCH STRATEGY:
Medline (1966-2013), Embase, the Cochrane Library and Web of Knowledge.
SELECTION CRITERIA:
Cohort or diagnostic accuracy studies of women with a singleton pregnancy, who had third-trimester imaging to predict macrosomia (>4000 g, >4500 g or >90th or >95th centile).
DATA COLLECTION AND ANALYSIS:
Two reviewers screened studies, performed data extraction and assessed methodological quality. The bivariate model was used to obtain summary sensitivities, specificities and likelihood ratios.
MAIN RESULTS:
Fifty-eight studies (34 367 pregnant women) were included. Most were poorly reported. Only one study assessed 3D ultrasound volumetry. For predicting birthweight >4000 g or >90th centile, the summary sensitivity for 2D ultrasound (Hadlock) estimated fetal weight (EFW) >90th centile or >4000 g (29 studies) was 0.56 (95% CI 0.49-0.61), 2D ultrasound abdominal circumference (AC) >35 cm (four studies) was 0.80 (95% confidence interval [95% CI] 0.69-0.87) and MRI EFW (three studies) was 0.93 (95% CI 0.76-0.98). The summary specificities were 0.92 (95% CI 0.90-0.94), 0.86 (95% CI 0.74-0.93) and 0.95 (95% CI 0.92-0.97), respectively.
CONCLUSION:
There is insufficient evidence to conclude that MRI EFW is more sensitive than 2D ultrasound AC (which is more sensitive than 2D EFW); although it was more specific. Further primary research is required before recommending MRI EFW for use in clinical practice. |
| first_indexed | 2025-11-14T19:13:47Z |
| format | Article |
| id | nottingham-31857 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:13:47Z |
| publishDate | 2016 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-318572020-05-04T20:04:40Z https://eprints.nottingham.ac.uk/31857/ Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis Malin, G.L. Bugg, George Takwoingi, Yemisi Thornton, Jim Jones, Nia W. BACKGROUND: Fetal macrosomia is associated with an increased risk of adverse maternal and neonatal outcomes. OBJECTIVES: To compare the accuracy of antenatal two-dimensional (2D) ultrasound, three-dimensional (3D) ultrasound, and magnetic resonance imaging (MRI) in predicting fetal macrosomia at birth. SEARCH STRATEGY: Medline (1966-2013), Embase, the Cochrane Library and Web of Knowledge. SELECTION CRITERIA: Cohort or diagnostic accuracy studies of women with a singleton pregnancy, who had third-trimester imaging to predict macrosomia (>4000 g, >4500 g or >90th or >95th centile). DATA COLLECTION AND ANALYSIS: Two reviewers screened studies, performed data extraction and assessed methodological quality. The bivariate model was used to obtain summary sensitivities, specificities and likelihood ratios. MAIN RESULTS: Fifty-eight studies (34 367 pregnant women) were included. Most were poorly reported. Only one study assessed 3D ultrasound volumetry. For predicting birthweight >4000 g or >90th centile, the summary sensitivity for 2D ultrasound (Hadlock) estimated fetal weight (EFW) >90th centile or >4000 g (29 studies) was 0.56 (95% CI 0.49-0.61), 2D ultrasound abdominal circumference (AC) >35 cm (four studies) was 0.80 (95% confidence interval [95% CI] 0.69-0.87) and MRI EFW (three studies) was 0.93 (95% CI 0.76-0.98). The summary specificities were 0.92 (95% CI 0.90-0.94), 0.86 (95% CI 0.74-0.93) and 0.95 (95% CI 0.92-0.97), respectively. CONCLUSION: There is insufficient evidence to conclude that MRI EFW is more sensitive than 2D ultrasound AC (which is more sensitive than 2D EFW); although it was more specific. Further primary research is required before recommending MRI EFW for use in clinical practice. Wiley 2016-01 Article PeerReviewed Malin, G.L., Bugg, George, Takwoingi, Yemisi, Thornton, Jim and Jones, Nia W. (2016) Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology, 123 (1). pp. 77-88. ISSN 1470-0328 Estimated fetal weight Macrosomia Magnetic resonance imaging Pregnancy Three-dimensional ultrasound Two dimensional ultrasound http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13517/abstract;jsessionid=70B22BB9687A48527FFA9225790EC1FA.f02t02? doi:10.1111/1471-0528.13517 doi:10.1111/1471-0528.13517 |
| spellingShingle | Estimated fetal weight Macrosomia Magnetic resonance imaging Pregnancy Three-dimensional ultrasound Two dimensional ultrasound Malin, G.L. Bugg, George Takwoingi, Yemisi Thornton, Jim Jones, Nia W. Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis |
| title | Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis |
| title_full | Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis |
| title_fullStr | Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis |
| title_full_unstemmed | Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis |
| title_short | Antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis |
| title_sort | antenatal magnetic resonance imaging versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis |
| topic | Estimated fetal weight Macrosomia Magnetic resonance imaging Pregnancy Three-dimensional ultrasound Two dimensional ultrasound |
| url | https://eprints.nottingham.ac.uk/31857/ https://eprints.nottingham.ac.uk/31857/ https://eprints.nottingham.ac.uk/31857/ |