Obesity appears to be associated with altered muscle protein synthetic and breakdown responses to increased nutrient delivery in older men, but not reduced muscle mass or contractile function.
Obesity is increasing, yet despite the necessity to maintain muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown. Eleven obese (BMI 31.9 ±1.1) and 15 healthy weight (HW; BMI 23.4 ±0.3) older men (55-75 years old) participated in a study...
| Main Authors: | Murton, Andrew J., Marimuthu, Kanagaraj, Mallinson, Joanne E., Selby, Anna L., Smith, Kenneth, Rennie, Michael J., Greenhaff, Paul L. |
|---|---|
| Format: | Article |
| Published: |
American Diabetes Association
2015
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/31815/ |
Similar Items
Human skeletal muscle disuse atrophy: effects on muscle protein synthesis, breakdown and insulin resistance- a qualitative review
by: Rudrappa, Supreeth S., et al.
Published: (2016)
by: Rudrappa, Supreeth S., et al.
Published: (2016)
Development and application of minimally invasive stable isotope tracers’ measures of muscle mass and muscle protein synthesis/breakdown: insights into ageing skeletal muscle
by: Cegielski, Jessica
Published: (2020)
by: Cegielski, Jessica
Published: (2020)
Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions
by: Phillips, Bethan E., et al.
Published: (2014)
by: Phillips, Bethan E., et al.
Published: (2014)
Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.
by: Mallinson, Joanne E., et al.
Published: (2015)
by: Mallinson, Joanne E., et al.
Published: (2015)
A novel puromycin decorporation method to quantify skeletal muscle protein breakdown: a proof-of-concept study
by: Crossland, Hannah, et al.
Published: (2017)
by: Crossland, Hannah, et al.
Published: (2017)
Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men
by: Atherton, Philip J., et al.
Published: (2016)
by: Atherton, Philip J., et al.
Published: (2016)
A constitutive model for cytoskeletal contractility of smooth muscle cells
by: Liu, Tao
Published: (2014)
by: Liu, Tao
Published: (2014)
Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes
by: Murton, Andrew J., et al.
Published: (2016)
by: Murton, Andrew J., et al.
Published: (2016)
Does muscle size matter?: The relationship between muscle size and strength in children with cerebral palsy
by: Reid, S., et al.
Published: (2015)
by: Reid, S., et al.
Published: (2015)
The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end points
by: Crossland, Hannah, et al.
Published: (2018)
by: Crossland, Hannah, et al.
Published: (2018)
Human muscle weakness and fatigue: the effects of disuse, age and exercise
by: White, Michael J.
Published: (1987)
by: White, Michael J.
Published: (1987)
Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats
by: Crossland, Hannah, et al.
Published: (2017)
by: Crossland, Hannah, et al.
Published: (2017)
A dose- rather than delivery profile-dependent mechanism regulates the "muscle-full" effect in response to oral essential amino acid intake in young men
by: Mitchell, William Kyle, et al.
Published: (2015)
by: Mitchell, William Kyle, et al.
Published: (2015)
The impact of delivery profile of essential amino acids upon skeletal muscle protein synthesis in older men: clinical efficacy of pulse vs. bolus supply
by: Mitchell, W. Kyle, et al.
Published: (2015)
by: Mitchell, W. Kyle, et al.
Published: (2015)
Differential nitric oxide levels in the blood and skeletal muscle of Type 2 diabetic subjects may be consequence of adiposity: a preliminary study.
by: Krause, M., et al.
Published: (2012)
by: Krause, M., et al.
Published: (2012)
Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men
by: Phillips, Bethan E., et al.
Published: (2016)
by: Phillips, Bethan E., et al.
Published: (2016)
Muscle architectural and physiological responses to immobilisation: impact of age and obesity
by: Ali, Arfan M.
Published: (2020)
by: Ali, Arfan M.
Published: (2020)
The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans
by: Wilkinson, Daniel J., et al.
Published: (2018)
by: Wilkinson, Daniel J., et al.
Published: (2018)
Electrospun gelatin-based scaffolds as a novel 3D platform to study the function of contractile smooth muscle cells in vitro
by: Bridge, Jack Christopher, et al.
Published: (2018)
by: Bridge, Jack Christopher, et al.
Published: (2018)
Characterisation of the anabolic effects of leucine on primary chicken muscle cells and murine C2C12 muscle cells
by: Elsaied, Nashwa
Published: (2021)
by: Elsaied, Nashwa
Published: (2021)
The roles of muscle contraction and pharmaceuticals on
restoring glucose uptake in a mouse skeletal muscle
model of immobilization
by: Kirkpatrick, Euan
Published: (2024)
by: Kirkpatrick, Euan
Published: (2024)
Supplementing essential amino acids with the nitric oxide precursor, l-arginine, enhances skeletal muscle perfusion without impacting anabolism in older men
by: Mitchell, W. Kyle, et al.
Published: (2017)
by: Mitchell, W. Kyle, et al.
Published: (2017)
The impacts of bed rest and acute trauma on muscle metabolic health in humans
by: Shur, Natalie F.
Published: (2024)
by: Shur, Natalie F.
Published: (2024)
The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells
by: Crossland, Hannah, et al.
Published: (2018)
by: Crossland, Hannah, et al.
Published: (2018)
Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent
by: Porter, Craig, et al.
Published: (2017)
by: Porter, Craig, et al.
Published: (2017)
Skeletal muscle remodeling in response to eccentric vs. concentric loading: morphological, molecular, and metabolic adaptations
by: Franchi, Martino V., et al.
Published: (2017)
by: Franchi, Martino V., et al.
Published: (2017)
Development and application of novel stable isotopic approaches to study human skeletal muscle in response to exercise and ageing
by: Brook, Matthew
Published: (2017)
by: Brook, Matthew
Published: (2017)
An in vitro and in silico study of altered airway smooth muscle structure and function in a remodelled asthmatic airway
by: Brown, Sarah
Published: (2023)
by: Brown, Sarah
Published: (2023)
Exploring the role of mitochondria in the changes seen in overall skeletal muscle health associated with ageing and cancer
by: Hatt, Jacob
Published: (2021)
by: Hatt, Jacob
Published: (2021)
Exploring mechanisms of disuse atrophy and optimal rehabilitation strategies for the restoration of muscle mass, structure & function
by: Inns, Thomas Benjamin
Published: (2023)
by: Inns, Thomas Benjamin
Published: (2023)
The role of skeletal muscle in the initiation and progression of knee osteoarthritis
by: Tonge, Daniel Paul
Published: (2010)
by: Tonge, Daniel Paul
Published: (2010)
Cytotoxic Effect of Betulinic Acid on Vascular Smooth Muscle Cells
by: Vadivelu, Raja Kumar
Published: (2009)
by: Vadivelu, Raja Kumar
Published: (2009)
Effect of footwear interventions on muscle discomfort and lower leg muscle fatigue among industrial workers
by: Omar, Noreen Adila
Published: (2021)
by: Omar, Noreen Adila
Published: (2021)
Muscle thickness measurements to estimate gluteus mediusand minimus activity levels
by: Dieterich, Angela, et al.
Published: (2014)
by: Dieterich, Angela, et al.
Published: (2014)
Utility of the precision cut lung slice model to investigate airway smooth muscle contraction
by: Fox, Jane
Published: (2011)
by: Fox, Jane
Published: (2011)
Sensory and motor effects of experimental muscle pain in patients with lateral epicondylalgia and controls with delayed onset muscle soreness
by: Slater, Helen, et al.
Published: (2005)
by: Slater, Helen, et al.
Published: (2005)
A randomised controlled trial of twelve months protein supplementation on muscle mass and strength in elderly women
by: Meng, Xingqiong (Rosie)
Published: (2010)
by: Meng, Xingqiong (Rosie)
Published: (2010)
The heterogeneity of the functional, metabolic, and molecular responses of skeletal muscle and clinical adaptations to exercise training in pre-clinical and human models
by: Farrash, Wesam
Published: (2020)
by: Farrash, Wesam
Published: (2020)
Effect of prototype armrest on comfort and muscle activity among selected male university motorcyclists during prolonged riding process
by: Alias, Ayuni Nabilah
Published: (2015)
by: Alias, Ayuni Nabilah
Published: (2015)
Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery
by: Varadhan, Krishna K., et al.
Published: (2017)
by: Varadhan, Krishna K., et al.
Published: (2017)
Similar Items
-
Human skeletal muscle disuse atrophy: effects on muscle protein synthesis, breakdown and insulin resistance- a qualitative review
by: Rudrappa, Supreeth S., et al.
Published: (2016) -
Development and application of minimally invasive stable isotope tracers’ measures of muscle mass and muscle protein synthesis/breakdown: insights into ageing skeletal muscle
by: Cegielski, Jessica
Published: (2020) -
Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions
by: Phillips, Bethan E., et al.
Published: (2014) -
Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.
by: Mallinson, Joanne E., et al.
Published: (2015) -
A novel puromycin decorporation method to quantify skeletal muscle protein breakdown: a proof-of-concept study
by: Crossland, Hannah, et al.
Published: (2017)