Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis
Pseudomonas aeruginosa chronically infects patients with cystic fibrosis and is associated with greater morbidity. There has been limited progress on the clinical development of new antibiotics with novel modes of action. This review addresses some of the latest research developments on the exploita...
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| Format: | Article |
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European Respiratory Society
2012
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| Online Access: | https://eprints.nottingham.ac.uk/3173/ |
| _version_ | 1848790969624821760 |
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| author | Hurley, M.N. Cámara, Miguel Smyth, Alan R. |
| author_facet | Hurley, M.N. Cámara, Miguel Smyth, Alan R. |
| author_sort | Hurley, M.N. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Pseudomonas aeruginosa chronically infects patients with cystic fibrosis and is associated with greater morbidity. There has been limited progress on the clinical development of new antibiotics with novel modes of action. This review addresses some of the latest research developments on the exploitation of candidate adjuvant therapeutic agents that may act alongside conventional antibiotics as an alternative therapeutic strategy. After considering key mechanisms this opportunistic pathogen employs to control virulence, the progress of various strategies including the inhibition of quorum sensing, efflux pumps and lectins, and the use of iron chelators, bacteriophages, immunisation and immunotherapy is reviewed. Both therapeutic approaches in early development and clinical phase are discussed. |
| first_indexed | 2025-11-14T18:21:03Z |
| format | Article |
| id | nottingham-3173 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:21:03Z |
| publishDate | 2012 |
| publisher | European Respiratory Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-31732020-05-04T16:33:54Z https://eprints.nottingham.ac.uk/3173/ Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis Hurley, M.N. Cámara, Miguel Smyth, Alan R. Pseudomonas aeruginosa chronically infects patients with cystic fibrosis and is associated with greater morbidity. There has been limited progress on the clinical development of new antibiotics with novel modes of action. This review addresses some of the latest research developments on the exploitation of candidate adjuvant therapeutic agents that may act alongside conventional antibiotics as an alternative therapeutic strategy. After considering key mechanisms this opportunistic pathogen employs to control virulence, the progress of various strategies including the inhibition of quorum sensing, efflux pumps and lectins, and the use of iron chelators, bacteriophages, immunisation and immunotherapy is reviewed. Both therapeutic approaches in early development and clinical phase are discussed. European Respiratory Society 2012-10-01 Article PeerReviewed Hurley, M.N., Cámara, Miguel and Smyth, Alan R. (2012) Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis. European Respiratory Journal, 40 (4). pp. 1014-1023. ISSN 0903-1936 Antibiotic resistance Antibiotic treatment Cystic fibrosis and chronic infections Pseudomonas http://erj.ersjournals.com/content/40/4/1014.abstract doi:10.1183/09031936.00042012 doi:10.1183/09031936.00042012 |
| spellingShingle | Antibiotic resistance Antibiotic treatment Cystic fibrosis and chronic infections Pseudomonas Hurley, M.N. Cámara, Miguel Smyth, Alan R. Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis |
| title | Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis |
| title_full | Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis |
| title_fullStr | Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis |
| title_full_unstemmed | Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis |
| title_short | Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis |
| title_sort | novel approaches to the treatment of pseudomonas aeruginosa infections in cystic fibrosis |
| topic | Antibiotic resistance Antibiotic treatment Cystic fibrosis and chronic infections Pseudomonas |
| url | https://eprints.nottingham.ac.uk/3173/ https://eprints.nottingham.ac.uk/3173/ https://eprints.nottingham.ac.uk/3173/ |