Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing
The recently released draft horse genome is incompletely characterised in terms of its repetitive element profile. This paper presents characterisation of the endogenous retrovirus (ERVs) of the horse genome based on a data-mining strategy using murine leukaemia virus proteins as queries. 978 ERV...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Elsevier
2012
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| Online Access: | https://eprints.nottingham.ac.uk/3169/ |
| _version_ | 1848790968267964416 |
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| author | Brown, Katherine Moreton, Joanna Malla, Sunir Aboobaker, A. Aziz Emes, Richard D. Tarlinton, Rachael E. |
| author_facet | Brown, Katherine Moreton, Joanna Malla, Sunir Aboobaker, A. Aziz Emes, Richard D. Tarlinton, Rachael E. |
| author_sort | Brown, Katherine |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The recently released draft horse genome is incompletely characterised in terms of its repetitive
element profile. This paper presents characterisation of the endogenous retrovirus (ERVs) of the horse
genome based on a data-mining strategy using murine leukaemia virus proteins as queries. 978 ERV
gene sequences were identified. Sequences were identified from the gamma, epsilon and betaretrovirus
genera. At least one full length gammaretroviral locus was identified, though the gammaretroviral
sequences are very degenerate. Using these data the RNA expression of these ERVs were derived from
RNA transcriptome data from a variety of equine tissues. Unlike the well studied human and murine
ERVs there do not appear to be particular phylogenetic groups of equine ERVs that are more
transcriptionally active. Using this novel approach provided a more technically feasible method to
characterise ERV expression than previous studies. |
| first_indexed | 2025-11-14T18:21:02Z |
| format | Article |
| id | nottingham-3169 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:21:02Z |
| publishDate | 2012 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-31692020-05-04T20:22:18Z https://eprints.nottingham.ac.uk/3169/ Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing Brown, Katherine Moreton, Joanna Malla, Sunir Aboobaker, A. Aziz Emes, Richard D. Tarlinton, Rachael E. The recently released draft horse genome is incompletely characterised in terms of its repetitive element profile. This paper presents characterisation of the endogenous retrovirus (ERVs) of the horse genome based on a data-mining strategy using murine leukaemia virus proteins as queries. 978 ERV gene sequences were identified. Sequences were identified from the gamma, epsilon and betaretrovirus genera. At least one full length gammaretroviral locus was identified, though the gammaretroviral sequences are very degenerate. Using these data the RNA expression of these ERVs were derived from RNA transcriptome data from a variety of equine tissues. Unlike the well studied human and murine ERVs there do not appear to be particular phylogenetic groups of equine ERVs that are more transcriptionally active. Using this novel approach provided a more technically feasible method to characterise ERV expression than previous studies. Elsevier 2012 Article PeerReviewed Brown, Katherine, Moreton, Joanna, Malla, Sunir, Aboobaker, A. Aziz, Emes, Richard D. and Tarlinton, Rachael E. (2012) Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing. Virology, 433 (1). pp. 55-63. ISSN 0042-6822 http://www.sciencedirect.com/science/article/pii/S0042682212003595 doi:10.1016/j.virol.2012.07.010 doi:10.1016/j.virol.2012.07.010 |
| spellingShingle | Brown, Katherine Moreton, Joanna Malla, Sunir Aboobaker, A. Aziz Emes, Richard D. Tarlinton, Rachael E. Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing |
| title | Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing |
| title_full | Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing |
| title_fullStr | Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing |
| title_full_unstemmed | Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing |
| title_short | Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing |
| title_sort | characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing |
| url | https://eprints.nottingham.ac.uk/3169/ https://eprints.nottingham.ac.uk/3169/ https://eprints.nottingham.ac.uk/3169/ |