The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: a randomised comparison

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The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: a randomised comparison

Background: Circadian variation in renal toxicity of aminoglycosides has been demonstrated in animal and human studies. People with CF are frequently prescribed aminoglycosides. Altered pharmacokinetics of aminoglycosides are predictive of toxicity. Aim: To investigate whether the time of day of am...

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Bibliographic Details
Main Authors:	Prayle, A.P., Jain, K., Touw, D.J., Koch, B.C.P., Knox, Alan J., Watson, A., Smyth, Alan R.
Format:	Article
Published:	Elsevier 2015
Subjects:	Cystic fibrosis; Aminoglycosides; Toxicity; Circadian rhythm
Online Access:	https://eprints.nottingham.ac.uk/31678/

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