C=N-containing azaarenes as activating groups in enantioselective catalysis
Nitrogen-containing aromatic heterocycles (azaarenes) are of widespread chemical significance, and chi-ral compounds containing azaarenes feature prominently in pharmaceuticals, agrochemicals, and natural products. This Perspective highlights the use of a relatively underdeveloped strategy to prepar...
| Main Authors: | , |
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| Format: | Article |
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American Chemical Society
2013
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| Online Access: | https://eprints.nottingham.ac.uk/31655/ |
| _version_ | 1848794246340935680 |
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| author | Best, Daniel Lam, Hon Wai |
| author_facet | Best, Daniel Lam, Hon Wai |
| author_sort | Best, Daniel |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Nitrogen-containing aromatic heterocycles (azaarenes) are of widespread chemical significance, and chi-ral compounds containing azaarenes feature prominently in pharmaceuticals, agrochemicals, and natural products. This Perspective highlights the use of a relatively underdeveloped strategy to prepare chiral azaarene-containing compounds: exploitation of the C=N bond embedded within certain azaarenes to activate adjacent functionality in catalytic asym-metric reactions. Work in this area has resulted in the development of several different types of catalytic enantioselec-tive processes, including reductions, nucleophilic additions, and reductive couplings. It is hoped that this Perspective will encourage more researchers to work in this promising area. |
| first_indexed | 2025-11-14T19:13:09Z |
| format | Article |
| id | nottingham-31655 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:13:09Z |
| publishDate | 2013 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-316552020-05-04T16:40:38Z https://eprints.nottingham.ac.uk/31655/ C=N-containing azaarenes as activating groups in enantioselective catalysis Best, Daniel Lam, Hon Wai Nitrogen-containing aromatic heterocycles (azaarenes) are of widespread chemical significance, and chi-ral compounds containing azaarenes feature prominently in pharmaceuticals, agrochemicals, and natural products. This Perspective highlights the use of a relatively underdeveloped strategy to prepare chiral azaarene-containing compounds: exploitation of the C=N bond embedded within certain azaarenes to activate adjacent functionality in catalytic asym-metric reactions. Work in this area has resulted in the development of several different types of catalytic enantioselec-tive processes, including reductions, nucleophilic additions, and reductive couplings. It is hoped that this Perspective will encourage more researchers to work in this promising area. American Chemical Society 2013-12-16 Article PeerReviewed Best, Daniel and Lam, Hon Wai (2013) C=N-containing azaarenes as activating groups in enantioselective catalysis. Journal of Organic Chemistry, 79 (3). pp. 831-845. ISSN 0022-3263 http://pubs.acs.org/doi/abs/10.1021/jo402414k doi:10.1021/jo402414k doi:10.1021/jo402414k |
| spellingShingle | Best, Daniel Lam, Hon Wai C=N-containing azaarenes as activating groups in enantioselective catalysis |
| title | C=N-containing azaarenes as activating groups in enantioselective catalysis |
| title_full | C=N-containing azaarenes as activating groups in enantioselective catalysis |
| title_fullStr | C=N-containing azaarenes as activating groups in enantioselective catalysis |
| title_full_unstemmed | C=N-containing azaarenes as activating groups in enantioselective catalysis |
| title_short | C=N-containing azaarenes as activating groups in enantioselective catalysis |
| title_sort | c=n-containing azaarenes as activating groups in enantioselective catalysis |
| url | https://eprints.nottingham.ac.uk/31655/ https://eprints.nottingham.ac.uk/31655/ https://eprints.nottingham.ac.uk/31655/ |