Characterisation of the horse transcriptome from immunologically active tissues
The immune system of the horse has not been well studied, despite the fact that the horse displays several features such as sensitivity to bacterial lipopolysaccharide that make them in many ways a more suitable model of some human disorders than the current rodent models. The difficulty of working...
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| Format: | Article |
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PeerJ
2014
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| Online Access: | https://eprints.nottingham.ac.uk/3162/ |
| _version_ | 1848790966581854208 |
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| author | Moreton, Joanna Malla, Sunir Aboobaker, Aziz Tarlinton, Rachael E. Emes, Richard D. |
| author_facet | Moreton, Joanna Malla, Sunir Aboobaker, Aziz Tarlinton, Rachael E. Emes, Richard D. |
| author_sort | Moreton, Joanna |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The immune system of the horse has not been well studied, despite the fact that the horse displays several features such as sensitivity to bacterial lipopolysaccharide that make them in many ways a more suitable model of some human disorders than the current rodent models. The difficulty of working with large animal models has however limited characterisation of gene expression in the horse immune system with current annotations for the equine genome restricted to predictions from other mammals and the few described horse proteins. This paper outlines sequencing of 184 million transcriptome short reads from immunologically active tissues of three horses including the genome reference “Twilight”. In a comparison with the Ensembl horse genome annotation, we found 8,763 potentially novel isoforms. |
| first_indexed | 2025-11-14T18:21:01Z |
| format | Article |
| id | nottingham-3162 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:21:01Z |
| publishDate | 2014 |
| publisher | PeerJ |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-31622020-05-04T16:48:22Z https://eprints.nottingham.ac.uk/3162/ Characterisation of the horse transcriptome from immunologically active tissues Moreton, Joanna Malla, Sunir Aboobaker, Aziz Tarlinton, Rachael E. Emes, Richard D. The immune system of the horse has not been well studied, despite the fact that the horse displays several features such as sensitivity to bacterial lipopolysaccharide that make them in many ways a more suitable model of some human disorders than the current rodent models. The difficulty of working with large animal models has however limited characterisation of gene expression in the horse immune system with current annotations for the equine genome restricted to predictions from other mammals and the few described horse proteins. This paper outlines sequencing of 184 million transcriptome short reads from immunologically active tissues of three horses including the genome reference “Twilight”. In a comparison with the Ensembl horse genome annotation, we found 8,763 potentially novel isoforms. PeerJ 2014-05-06 Article PeerReviewed Moreton, Joanna, Malla, Sunir, Aboobaker, Aziz, Tarlinton, Rachael E. and Emes, Richard D. (2014) Characterisation of the horse transcriptome from immunologically active tissues. PeerJ . ISSN 2167-8359 https://peerj.com/articles/382/ doi:10.7717/peerj.382 doi:10.7717/peerj.382 |
| spellingShingle | Moreton, Joanna Malla, Sunir Aboobaker, Aziz Tarlinton, Rachael E. Emes, Richard D. Characterisation of the horse transcriptome from immunologically active tissues |
| title | Characterisation of the horse transcriptome from immunologically active tissues |
| title_full | Characterisation of the horse transcriptome from immunologically active tissues |
| title_fullStr | Characterisation of the horse transcriptome from immunologically active tissues |
| title_full_unstemmed | Characterisation of the horse transcriptome from immunologically active tissues |
| title_short | Characterisation of the horse transcriptome from immunologically active tissues |
| title_sort | characterisation of the horse transcriptome from immunologically active tissues |
| url | https://eprints.nottingham.ac.uk/3162/ https://eprints.nottingham.ac.uk/3162/ https://eprints.nottingham.ac.uk/3162/ |