Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island"
The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture. While this is certainly true, we hypothesize that pro...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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Springer
2015
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| Online Access: | https://eprints.nottingham.ac.uk/31618/ |
| _version_ | 1848794237191061504 |
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| author | Hao, Xiuli Luthje, Freja L. Qin, Yanan McDevitt, Sylvia Franke Lutay, Nataliya Hobman, John L. Asiani, Karishma Soncini, Fernando C. German, Nadezhda Zhang, Siyu Zhu, Yong-Guan Rensing, Christopher |
| author_facet | Hao, Xiuli Luthje, Freja L. Qin, Yanan McDevitt, Sylvia Franke Lutay, Nataliya Hobman, John L. Asiani, Karishma Soncini, Fernando C. German, Nadezhda Zhang, Siyu Zhu, Yong-Guan Rensing, Christopher |
| author_sort | Hao, Xiuli |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture. While this is certainly true, we hypothesize that protozoan predation and macrophage killing are also responsible for selection of copper/zinc resistance genes in bacteria. In this review, we outline evidence supporting this hypothesis, as well as highlight the correlation between metal resistance and pathogenicity in bacteria. In addition, we introduce and characterize the "copper pathogenicity island" identified in Escherichia coli and Salmonella strains isolated from copper- and zinc-fed Danish pigs. |
| first_indexed | 2025-11-14T19:13:00Z |
| format | Article |
| id | nottingham-31618 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:13:00Z |
| publishDate | 2015 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-316182020-05-04T20:08:07Z https://eprints.nottingham.ac.uk/31618/ Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" Hao, Xiuli Luthje, Freja L. Qin, Yanan McDevitt, Sylvia Franke Lutay, Nataliya Hobman, John L. Asiani, Karishma Soncini, Fernando C. German, Nadezhda Zhang, Siyu Zhu, Yong-Guan Rensing, Christopher The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture. While this is certainly true, we hypothesize that protozoan predation and macrophage killing are also responsible for selection of copper/zinc resistance genes in bacteria. In this review, we outline evidence supporting this hypothesis, as well as highlight the correlation between metal resistance and pathogenicity in bacteria. In addition, we introduce and characterize the "copper pathogenicity island" identified in Escherichia coli and Salmonella strains isolated from copper- and zinc-fed Danish pigs. Springer 2015-07 Article PeerReviewed Hao, Xiuli, Luthje, Freja L., Qin, Yanan, McDevitt, Sylvia Franke, Lutay, Nataliya, Hobman, John L., Asiani, Karishma, Soncini, Fernando C., German, Nadezhda, Zhang, Siyu, Zhu, Yong-Guan and Rensing, Christopher (2015) Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island". Applied Microbiology and Biotechnology, 99 (14). pp. 5817-5824. ISSN 1432-0614 Copper Pathogenicity Amoeba Grazing resistance http://link.springer.com/article/10.1007/s00253-015-6749-0 doi:10.1007/s00253-015-6749-0 doi:10.1007/s00253-015-6749-0 |
| spellingShingle | Copper Pathogenicity Amoeba Grazing resistance Hao, Xiuli Luthje, Freja L. Qin, Yanan McDevitt, Sylvia Franke Lutay, Nataliya Hobman, John L. Asiani, Karishma Soncini, Fernando C. German, Nadezhda Zhang, Siyu Zhu, Yong-Guan Rensing, Christopher Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" |
| title | Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" |
| title_full | Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" |
| title_fullStr | Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" |
| title_full_unstemmed | Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" |
| title_short | Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" |
| title_sort | survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" |
| topic | Copper Pathogenicity Amoeba Grazing resistance |
| url | https://eprints.nottingham.ac.uk/31618/ https://eprints.nottingham.ac.uk/31618/ https://eprints.nottingham.ac.uk/31618/ |